Author's Reply: Critical Limitations in Systematic Reviews of Large Language Models in Health Care

Andre Python^{1

2

3}, HongYi Li^{1

4}, Jun-Fen Fu^{5

6

7}

Affiliations

¹ Center for Data Science, Zhejiang University, Hangzhou, China.
² School of Medicine, Zhejiang University, Hangzhou, China.
³ Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, United Kingdom, 44 01865 287500.
⁴ School of Mathematical Sciences, Zhejiang University, Hangzhou, China.
⁵ School of Medicine, Children's Hospital of Zhejiang University, Hangzhou, China.
⁶ National Clinical Research Center for Child Health, Hangzhou, China.
⁷ National Regional Center for Children's Health, Hangzhou, China.

Andre Python et al. J Med Internet Res. 2025.

. 2025 Sep 24:27:e82729.

doi: 10.2196/82729.

Andre Python^{1

2

3}, HongYi Li^{1

4}, Jun-Fen Fu^{5

6

7}

¹ Center for Data Science, Zhejiang University, Hangzhou, China.
² School of Medicine, Zhejiang University, Hangzhou, China.
³ Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, United Kingdom, 44 01865 287500.
⁴ School of Mathematical Sciences, Zhejiang University, Hangzhou, China.
⁵ School of Medicine, Children's Hospital of Zhejiang University, Hangzhou, China.
⁶ National Clinical Research Center for Child Health, Hangzhou, China.
⁷ National Regional Center for Children's Health, Hangzhou, China.

No abstract available

Keywords: AI; LLM; LLM review; artificial intelligence; clinical; digital health; large language model; letter; review.

Conflict of interest statement

Conflicts of Interest: None declared.

1. Li H, Fu JF, Python A. Implementing large language models in health care: clinician-focused review with interactive guideline. J Med Internet Res. 2025 Jul 11;27:e71916. doi: 10.2196/71916. doi. Medline. - DOI - PMC - PubMed
1. Weizman Z. Critical limitations in systematic reviews of large language models in health care. J Med Internet Res. 2025;27:e81769. doi: 10.2196/81769. doi. - DOI - PMC - PubMed
1. Liu F, Zhou H, Gu B, et al. Application of large language models in medicine. Nat Rev Bioeng. 2025;3(6):445–464. doi: 10.1038/s44222-025-00279-5. doi. - DOI
1. Page MJ, McKenzie JE, Bossuyt PM, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021 Mar 29;372:n71. doi: 10.1136/bmj.n71. doi. Medline. - DOI - PMC - PubMed
1. Betzler BK, Chen H, Cheng CY, et al. Large language models and their impact in ophthalmology. Lancet Digit Health. 2023 Dec;5(12):e917–e924. doi: 10.1016/S2589-7500(23)00201-7. doi. Medline. - DOI - PMC - PubMed