Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2025 Oct 1;53(4):187-194.
doi: 10.1249/JES.0000000000000370. Epub 2025 Sep 22.

Exercise to Mitigate Premature Vascular Aging After Doxorubicin Breast Cancer Therapy

Zachary S Clayton  1 , Branden L Nguyen  1 , Ravinandan Venkatasubramanian  1 , Peter Kabos  2
Affiliations
Review

Exercise to Mitigate Premature Vascular Aging After Doxorubicin Breast Cancer Therapy

Zachary S Clayton et al. Exerc Sport Sci Rev. .

Abstract

Breast cancer treatment induces a state of premature vascular aging. This article examines the hypothesis that high-intensity interval training may be a time-efficient form of exercise training that effectively mitigates premature vascular aging in breast cancer survivors.

Keywords: adjuvant breast cancer therapy; breast cancer; chemotherapy; exercise; oxidative stress; vascular aging.

PubMed Disclaimer

References

    1. Timmis A, Townsend N, Gale CP, et al.; European Society of Cardiology. European Society of Cardiology: cardiovascular disease statistics 2019. Eur. Heart J. 2020;41(1) 12–85.
    1. Jaul E, Barron J. Age-related diseases and clinical and public health implications for the 85 years old and over population. Front. Public Health. 2017;5:335.
    1. Lakatta EG, Levy D. Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: part I: aging arteries: a “set up” for vascular disease. Circulation. 2003;107(1) 139–46.
    1. Seals DR, Jablonski KL, Donato AJ. Aging and vascular endothelial function in humans. Clin. Sci. (Lond). 2011;120(9) 357–75.
    1. Donato AJ, Morgan RG, Walker AE, Lesniewski LA. Cellular and molecular biology of aging endothelial cells. J. Mol. Cell. Cardiol. 2015;89(Pt B):122–35.

MeSH terms

LinkOut - more resources