Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2025 Sep 22;13(9):e70993.
doi: 10.1002/fsn3.70993. eCollection 2025 Sep.

A Comprehensive Review on Anxiolytic Effect of Lavandula Angustifolia Mill. in Clinical Studies

Sana Manzoor  1   2 , Allah Rakha  1 , Hina Rasheed  1 , Zuhaib F Bhat  3 , Muhammad Shaffay Ali Khan  4 , Gholamreza Abdi  5 , Rana Muhammad Aadil  1
Affiliations
Review

A Comprehensive Review on Anxiolytic Effect of Lavandula Angustifolia Mill. in Clinical Studies

Sana Manzoor et al. Food Sci Nutr. .

Abstract

Lavandula angustifolia, a fragrant but bitter flower generally termed lavender, has been exploited for years as a therapy for distinct ailments. It can act as an antispasmodic, analgesic, hypotensive, antiseptic, antimicrobial, and tonic effects that promoting overall health and vitality. This review critically appraises the major bioactive components of lavender and their anxiolytic effects. These key elements interact with the nervous and endocrine systems to modulate the pathophysiology and improve mood and behavior. They modulate the GABA receptors to relax the neurons, spare more serotonin in synapses, and channelize neurotransmitters through distinct signaling cascades. Several clinical trials have demonstrated the anxiolytic potential of oral lavender, with minimal side effects, in human subjects. Therefore, exploiting the herbs for therapeutic purposes, that is, lavender for anxiety, is a safer approach to managing anxiety and preserving mental health and well-being.

Keywords: anxiety; anxiolytic property; essential oils; lavender; volatile compounds.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflicts of interest.

Figures

FIGURE 1
FIGURE 1
Biosynthesis of active ingredients in lavender.
See this image and copyright information in PMC

References

    1. Abbaszadeh, R. , Tabari F., and Asadpour A.. 2020. “The Effect of Lavender Aroma on Anxiety of Patients Having Bone Marrow Biopsy.” Asian Pacific Journal of Cancer Prevention: APJCP 21: 771–775. - PMC - PubMed
    1. Abd Alkhalek, W. M. 2023. “Clinical Evaluation of the Effect of Volatile Oils on Anxiety of Children During Dental Procedures: An In‐Vivo Study.” Dental Journal (Majalah Kedokteran Gigi) 69: 927.
    1. Abduallah, A. M. , Ahmed A. E., Bajaber M. A., and Alalwiat A. A.. 2023. “Evaluation of the Antidiabetic Effects of Methanolic Extracts of Neem (<styled-content style="fixed-case"> Azadirachta Indica </styled-content>) Seeds on the Streptozotocin‐Induced Wistar Rats.” Pakistan Veterinary Journal 43, no. 4: 792–798.
    1. Abubakar, A. R. , and Haque M.. 2020. “Preparation of Medicinal Plants: Basic Extraction and Fractionation Procedures for Experimental Purposes.” Journal of Pharmacy & Bioallied Sciences 12: 1–10. - PMC - PubMed
    1. Afshar, M. K. , Moghadam Z. B., Taghizadeh Z., Bekhradi R., Montazeri A., and Mokhtari P.. 2015. “Lavender Fragrance Essential Oil and the Quality of Sleep in Postpartum Women.” Iranian Red Crescent Medical Journal 17: e25880. - PMC - PubMed

LinkOut - more resources