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Editorial
. 2025 Sep 25;66(3):2501267.
doi: 10.1183/13993003.01267-2025. Print 2025 Sep.

Dissecting the genetics of chronic cough

Alyn Hugh Morice  1
Affiliations
Editorial

Dissecting the genetics of chronic cough

Alyn Hugh Morice. Eur Respir J. .

Abstract

Gene signatures are shared between chronic cough and ACE inhibitor cough https://bit.ly/45juEw2

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Conflict of interest statement

Conflict of interest: A.H. Morice reports consultancy fees from Bellus, GSK, NeRRi and Trevi, payment or honoraria for lectures, presentations, manuscript writing or educational events from GSK, Merck and Hilton, grant support from Axalbion, Bellus, GSK, Merck, Nocion, Philips, NeRRi and Trevi, and participation on a data safety monitoring board or advisory board with Boehringer Ingelheim.

Comment on

  • Genomics of chronic dry cough unravels neurological pathways.
    Coley K, John C, Ghouse J, Shepherd DJ, Shrine N, Izquierdo AG, Kanoni S, Magavern EF, Packer R, McGarvey L, Smith JA, Bundgaard H, Ostrowski SR, Erikstrup C, Pedersen OBV, van Heel DA; Genes and Health Research Team; Hennah W, Marttila M, Free RC, Hollox EJ, Wain LV, Tobin MD, Batini C. Coley K, et al. Eur Respir J. 2025 Sep 25;66(3):2402341. doi: 10.1183/13993003.02341-2024. Print 2025 Sep. Eur Respir J. 2025. PMID: 40675770 Free PMC article.

References

    1. Morice AH, Lowry R, Brown MJ, et al. Angiotensin converting enzyme and the cough reflex. Lancet 1987; 2: 1116–1118. doi: 10.1016/S0140-6736(87)91547-9 - DOI - PubMed
    1. Smith J, Allman D, Badri H, et al. The neurokinin-1 receptor antagonist orvepitant is a novel antitussive therapy for chronic refractory cough: results from a phase 2 pilot study (VOLCANO-1). Chest 2020; 157: 111–118. doi: 10.1016/j.chest.2019.08.001 - DOI - PubMed
    1. Emilsson ÖI, Johansson H, Johannessen A, et al. Heritability of cough across two generations: the RHINESSA study. ERJ Open Res 2024; 10: 00071-2024. doi: 10.1183/23120541.00071-2024 - DOI - PMC - PubMed
    1. Coley K, John C, Ghouse J, et al. Genomics of chronic dry cough unravels neurological pathways. Eur Respir J 2025; 66: 2402341. doi: 10.1183/13993003.02341-2024 - DOI - PMC - PubMed
    1. Morice AH, Faruqi S, Wright CE, et al. Cough hypersensitivity syndrome: a distinct clinical entity. Lung 2011; 189: 73–79. doi: 10.1007/s00408-010-9272-1 - DOI - PubMed

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