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. 2025 Sep 24.
doi: 10.1039/d5sc90195b. Online ahead of print.

A reflection on frustrated Lewis pairs 20 years on: the gift that keeps on giving

Rebecca L Melen  1 , Douglas W Stephan  2
Affiliations

A reflection on frustrated Lewis pairs 20 years on: the gift that keeps on giving

Rebecca L Melen et al. Chem Sci. .

Abstract

This commentary reflects on the remarkably broad impact the concept of "frustrated Lewis pairs" (FLPs) has had over the past 20 years. Since its initial articulation, this concept has found applications across the periodic table and the discipline, leading to new avenues for synthesis and catalysis, building on the 2011 publication (R. C. Neu, E. Otten, A. Lough and D. W. Stephan, Chem. Sci., 2011, 2, 170, https://doi.org/10.1039/C0SC00398K).

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Conflict of interest statement

There are no conflicts to declare.

Figures

Fig. 1
Fig. 1. The diversity of chemistry emerging from FLPs. ED = electron donor; EA = electron acceptor; LB = Lewis base; LA = Lewis acid.
See this image and copyright information in PMC

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