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Case Reports
. 2025 Sep 24;12(9):e01790.
doi: 10.14309/crj.0000000000001790. eCollection 2025 Sep.

Isolated Gastric Crohn's Disease

Matthew Udine  1 , Andres Rodriguez  1 , Ankita Tirath  1 , Heba Iskandar  1
Affiliations
Case Reports

Isolated Gastric Crohn's Disease

Matthew Udine et al. ACG Case Rep J. .

Abstract

Isolated gastric Crohn's Disease (IGCD) is a rare subset of Crohn's disease, poorly described in the literature. In this article, we present a 21-year-old man with gastric outlet obstruction secondary to IGCD. Management with Adalimumab and Upadacitinib failed, however he responded to Risankizumab. To our knowledge, this is the first case report documenting efficacy of Risankizumab in management of IGCD. In addition, we reviewed 13 published case reports describing IGCD. Ninety-two percent of cases were seen in women, typically presenting with nausea/vomiting and abdominal pain. Eighty-five percent of cases progressed to gastric outlet obstruction and tumor necrosis factor inhibitors were the first line advanced therapy.

Keywords: Crohn's Disease; gastric outlet obstruction; inflammatory bowel disease.

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Figures

Figure 1.
Figure 1.
Gastric outlet obstruction seen on magnetic resonance imaging.
Figure 2.
Figure 2.
Severe gastritis with gastric antral stenosis.
Figure 3.
Figure 3.
Healing gastric mucosa following Risankizumab therapy.
See this image and copyright information in PMC

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