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Review
. 2025:1481:29-69.
doi: 10.1007/978-3-031-92785-0_2.

Efferocytosis in Homeostasis

Christian Maueröder  1   2 , Caitlin M Gillis  1   2 , Kodi S Ravichandran  3   4   5
Affiliations
Review

Efferocytosis in Homeostasis

Christian Maueröder et al. Adv Exp Med Biol. 2025.

Abstract

Apoptotic cells are removed by professional and nonprofessional phagocytes via the process of "efferocytosis." Efferocytosis is highly efficient such that accumulation of dead cells is rarely seen in healthy tissues, even though our bodies remove 200-400 billion apoptotic cells daily. Besides clearing apoptotic cells, efferocytosis also has many beneficial roles, including secretion of anti-inflammatory mediators and promotion of local tissue repair. Thus, impairments in efferocytosis interfere with normal function in tissues. In this review, we will focus on how efferocytosis supports the return to homeostasis following inflammation and injury. Further, we highlight maladaptive responses when efferocytosis is disrupted, contributing to autoimmunity and fibrosis.

Keywords: Apoptosis; Asthma; Dead cell clearance in the testes; Efferocytosis; Fibrosis; Homeostasis; Immune tolerance; Lung inflammation; Mammary involution; SLE; Tissue repair.

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References

    1. de Cathelineau, A. M., & Henson, P. M. (2003). The final step in programmed cell death: Phagocytes carry apoptotic cells to the grave. Essays in Biochemistry, 39, 105–117. https://doi.org/10.1042/bse0390105 - DOI
    1. Kerr, J. F., Wyllie, A. H., & Currie, A. R. (1972). Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics. British Journal of Cancer, 26, 239–257. - DOI - PubMed - PMC
    1. Tak, T., Tesselaar, K., Pillay, J., Borghans, J. A., & Koenderman, L. (2013). What’s your age again? Determination of human neutrophil half-lives revisited. Journal of Leukocyte Biology, 94, 595–601. https://doi.org/10.1189/jlb.1112571 - DOI - PubMed
    1. Vandivier, R. W., Henson, P. M., & Douglas, I. S. (2006). Burying the dead: The impact of failed apoptotic cell removal (efferocytosis) on chronic inflammatory lung disease. Chest, 129, 1673–1682. https://doi.org/10.1378/chest.129.6.1673 - DOI - PubMed
    1. Medina, C. B., et al. (2020). Metabolites released from apoptotic cells act as tissue messengers. Nature, 580, 130–135. https://doi.org/10.1038/s41586-020-2121-3 - DOI - PubMed - PMC

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