The misleading accuracy of propofol PK/PD models: why hypoalbuminemia matters

Manon Launay¹, Peggy Gandia^{2

3}, Aline Albi-Feldzer⁴, Audrey Bellesoeur¹, Pierre-Louis Toutain⁵, Mary Saad-Boutry^{4

6}

Affiliations

¹ Department of Pharmacology, Institut Curie, PSL Research University, Saint-Cloud, France.
² Pharmacokinetics and Toxicology Laboratory, Federative Institute of Biology, Toulouse University Hospital, Toulouse, France.
³ INTHERES, University of Toulouse, INRAE, ENVT, Toulouse, France.
⁴ Department of Anaesthesia, Institut Curie, EPST, PSL Research University, Saint Cloud, France.
⁵ Department of Comparative Biomedical Sciences, The Royal Veterinary College, University of London, London, UK.
⁶ Computational Oncology, U1331, INSERM, Paris, France.

Editorial

Manon Launay et al. Expert Opin Drug Metab Toxicol. 2025 Oct.

. 2025 Oct;21(10):1131-1134.

doi: 10.1080/17425255.2025.2568190. Epub 2025 Oct 7.

Manon Launay¹, Peggy Gandia^{2

3}, Aline Albi-Feldzer⁴, Audrey Bellesoeur¹, Pierre-Louis Toutain⁵, Mary Saad-Boutry^{4

6}

¹ Department of Pharmacology, Institut Curie, PSL Research University, Saint-Cloud, France.
² Pharmacokinetics and Toxicology Laboratory, Federative Institute of Biology, Toulouse University Hospital, Toulouse, France.
³ INTHERES, University of Toulouse, INRAE, ENVT, Toulouse, France.
⁴ Department of Anaesthesia, Institut Curie, EPST, PSL Research University, Saint Cloud, France.
⁵ Department of Comparative Biomedical Sciences, The Royal Veterinary College, University of London, London, UK.
⁶ Computational Oncology, U1331, INSERM, Paris, France.

No abstract available

Keywords: Propofol; hypoalbuminemia; marsh model; schnider model; target-controlled infusion.

Publication types