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. 1977 Aug 31;54(1):45-9.
doi: 10.1007/BF00426540.

The effects of methaqualone on the seizure susceptibility of mice

W O Boggan, J S Meyer, R M Steinberg, C Worthington

The effects of methaqualone on the seizure susceptibility of mice

W O Boggan et al. Psychopharmacology (Berl). .

Abstract

Methaqualone produces dose- and time-dependent decreases in susceptibility to electrically, chemically, and sound-induced seizures. The antagonism of methaqualone to electroconvulsive shock can be dissociated from its effects on temperature regulation and plasma corticosterone. Studies with SKF525A, a drug known to block enzymes in the liver that metabolize drugs, suggest that methaqualone, rather than a metabolite produced in the liver, is responsible for its anticonvulsant effects. Tolerance to the anticonvulsant effects of methaqualone is also demonstrated.

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