Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2025 Oct;24(10):e70450.
doi: 10.1111/jocd.70450.

Comparison of Visible Light-Protective Tinted Sunscreen to Untinted Sunscreen to Protect Melasma Patients During Summer: A Prospective Randomized Investigator-Blinded Study

Affiliations

Comparison of Visible Light-Protective Tinted Sunscreen to Untinted Sunscreen to Protect Melasma Patients During Summer: A Prospective Randomized Investigator-Blinded Study

Helena Polena et al. J Cosmet Dermatol. 2025 Oct.
No abstract available

Keywords: melasma; photoprotection; skin pigmentation; tinted sunscreen; visible light.

PubMed Disclaimer

Conflict of interest statement

H.P., C.G., and M.S. are or were employees of NAOS. T.P. has received honoraria from Beiersdorf, Galderma, L'Oréal, Hyphens, ISIS Pharma, ISDIN, NAOS, Pierre Fabre, SUN Pharma, SVR, and Symrise.

Figures

FIGURE 1
FIGURE 1
Evolution of (a) ∆L* and L* (lightness), (b) ∆ITA° and ITA° (pigmentation), and (c) ∆E (color homogeneity) parameters. For all parameters, variations (∆) between the melasma affected and unaffected areas in the untinted and tinted groups are presented as histograms. Mean parameter values (L* and ITA°) for the melasma affected and unaffected areas in the untinted and tinted groups are presented as dots and lines. Inter‐group differences (°) were assessed using unpaired t‐test at identical timepoints. Intra‐group differences (*) versus baseline were analyzed using Dunnett's adjustments for variations (∆) and paired t‐test for L* and ITA°. Statistical differences are reported with * or °: p < 0.05, **: p < 0.01, and ***: p < 0.001.
FIGURE 2
FIGURE 2
Photographs of two subjects who applied the untinted or the tinted sunscreen for 5 months.

References

    1. Mahmoud B. H., Ruvolo E., Hexsel C. L., et al., “Impact of Long‐Wavelength UVA and Visible Light on Melanocompetent Skin,” Journal of Investigative Dermatology 130, no. 8 (2010): 2092–2097, 10.1111/jdv.15186. - DOI - PubMed
    1. Lyons A. B., Trullas C., Kohli I., Hamzavi I. H., and Lim H. W., “Photoprotection Beyond Ultraviolet Radiation: A Review of Tinted Sunscreens,” Journal of the American Academy of Dermatology 84, no. 5 (2021): 1393–1397, 10.1016/j.jaad.2020.04.079. - DOI - PubMed
    1. Morgado‐Carrasco D., Piquero‐Casals J., Granger C., Trullàs C., and Passeron T., “Melasma: The Need for Tailored Photoprotection to Improve Clinical Outcomes,” Photodermatology, Photoimmunology & Photomedicine 38, no. 6 (2022): 515–521, 10.1111/phpp.12783. - DOI - PMC - PubMed
    1. Duteil L., Cadars B., Queille‐Roussel C., et al., “A New In Vitro Method to Predict in Vivo Photoprotection of Skin Hyperpigmentation Induced by Visible Light,” Journal of the European Academy of Dermatology and Venereology 36, no. 6 (2022): 922–926, 10.1111/jdv.18034. - DOI - PMC - PubMed
    1. Pandya A. G., Hynan L. S., Bhore R., et al., “Reliability Assessment and Validation of the Melasma Area and Severity Index (MASI) and a New Modified MASI Scoring Method,” Journal of the American Academy of Dermatology 64, no. 1 (2011): 78–83, 10.1016/j.jaad.2009.10.051. - DOI - PubMed

LinkOut - more resources