Tezepelumab Targeting Thymic Stromal Lymphopoietin Enhances Steroid Sensitivity in Patients With Severe Asthma

Keita Hirai^{1

2

3}, Sekiko Uehara³, Toshihiro Shirai⁴, Taisuke Akamatsu⁴, Kunihiko Itoh^{3

5}

Affiliations

¹ Department of Clinical Pharmacology and Therapeutics, Shinshu University Graduate School of Medicine, Matsumoto, Japan.
² Department of Pharmacy, Shinshu University Hospital, Matsumoto, Japan.
³ Department of Clinical Pharmacology & Genetics, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan.
⁴ Department of Respiratory Medicine, Shizuoka General Hospital, Shizuoka, Japan.
⁵ Laboratory of Clinical Pharmacogenomics, Shizuoka General Hospital, Shizuoka, Japan.

Keita Hirai et al. Allergy. 2025.

. 2025 Sep 27.

doi: 10.1111/all.70083. Online ahead of print.

Keita Hirai^{1

2

3}, Sekiko Uehara³, Toshihiro Shirai⁴, Taisuke Akamatsu⁴, Kunihiko Itoh^{3

5}

¹ Department of Clinical Pharmacology and Therapeutics, Shinshu University Graduate School of Medicine, Matsumoto, Japan.
² Department of Pharmacy, Shinshu University Hospital, Matsumoto, Japan.
³ Department of Clinical Pharmacology & Genetics, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan.
⁴ Department of Respiratory Medicine, Shizuoka General Hospital, Shizuoka, Japan.
⁵ Laboratory of Clinical Pharmacogenomics, Shizuoka General Hospital, Shizuoka, Japan.

No abstract available

Keywords: asthma; biologics; steroid sensitivity; thymic stromal lymphopoietin.

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