Expanding the framework on multimodal biomarkers in isolated REM sleep behavior disorder: Response to Carpi et al

Giulia Bruschi^{1

2}, Elisa Bortolin^{1

2}, Maria Vittoria Corbari¹, Alessandro Bombaci^{2

3}, Salvatore Mazzeo^{2

3}, Massimo Filippi⁴, Maria Salsone^{2

3}

Affiliations

¹ Department of Psychology, Vita-Salute San Raffaele University, Via Olgettina 60, 20132 Milan, Italy.
² Neurology Unit, IRCCS Policlinico San Donato, Piazza Edmondo Malan 2, 20097 San Donato Milanese, Italy.
³ Department of Neurology, Vita-Salute San Raffaele University, Via Olgettina 60, 20132 Milan, Italy.
⁴ Department of Neurology, Vita-Salute San Raffaele University, and Neurology Unit, Neurorehabilitation Unit, and Neurophysiology Service, IRCCS Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy.

Editorial

Giulia Bruschi et al. Sleep. 2025.

. 2025 Dec 11;48(12):zsaf303.

doi: 10.1093/sleep/zsaf303.

Giulia Bruschi^{1

2}, Elisa Bortolin^{1

2}, Maria Vittoria Corbari¹, Alessandro Bombaci^{2

3}, Salvatore Mazzeo^{2

3}, Massimo Filippi⁴, Maria Salsone^{2

3}

¹ Department of Psychology, Vita-Salute San Raffaele University, Via Olgettina 60, 20132 Milan, Italy.
² Neurology Unit, IRCCS Policlinico San Donato, Piazza Edmondo Malan 2, 20097 San Donato Milanese, Italy.
³ Department of Neurology, Vita-Salute San Raffaele University, Via Olgettina 60, 20132 Milan, Italy.
⁴ Department of Neurology, Vita-Salute San Raffaele University, and Neurology Unit, Neurorehabilitation Unit, and Neurophysiology Service, IRCCS Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy.

No abstract available

Keywords: biomarker; isolated REM sleep behavior disorder (iRBD); prodromal α-synucleinopathies.

Comment on

The quest for biomarkers in isolated REM sleep behavior disorder. Comment on Bruschi et al.
Carpi M, Fernandes M, Liguori C. Carpi M, et al. Sleep. 2025 Dec 11;48(12):zsaf261. doi: 10.1093/sleep/zsaf261. Sleep. 2025. PMID: 40891495 No abstract available.