Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2025 Oct;31(10):1992-1997.
doi: 10.3201/eid3110.250464.

Antimicrobial-Resistant Clonal Complex 11 Neisseria meningitidis-Associated Urethritis Cluster, Thailand

John C Cartee, Thitima Cherdtrakulkiat, Sandeep J Joseph, Rossaphorn Kittiyaowamarn, Natnaree Girdthep, Pongsathorn Sangprasert, Porntip Paopang, Thidathip Wongsurawat, Piroon Jenjaroenpun, Perapon Nitayanon, Rebekah Frankson, Silvina Masciotra, Teodora Wi, Ismael Maatouk, Ellen N Kersh, Andrey S Borisov, Chanwit Tribuddharat

Antimicrobial-Resistant Clonal Complex 11 Neisseria meningitidis-Associated Urethritis Cluster, Thailand

John C Cartee et al. Emerg Infect Dis. 2025 Oct.

Abstract

Sexually transmitted infections clinics in Bangkok, Thailand, reported increasing numbers of men with Neisseria meningitidis-associated urethritis during 2017-2023. Genomic analysis indicated global expansion of the nongroupable clonal complex 11 N. meningitidis urethritis clade. Continued global surveillance is needed to monitor the spread of antimicrobial-resistant N. meningitidis with urethral adaptability.

Keywords: AMR; Neisseria meningitidis; Thailand; antimicrobial resistance; bacteria; gonorrhea; meningococcal urethritis; sexually transmitted infections; urethritis.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Maximum-likelihood phylogenetic tree from investigation of antimicrobial-resistant clonal complex 11 Neisseria meningitidis–associated urethritis cluster, Thailand. The tree is based on core-genome single-nucleotide polymorphisms of 259 clonal complex 11 N. meningitidis isolates collected from symptomatic male urethritis patients, representing the N. meningitidis urethritis clade. Scale bar indicates nucleotide substitutions per site. NmUC-B, N. meningitidis urethritis clade–subclade B.
Figure 2
Figure 2
Maximum-likelihood phylogenetic tree of clonal complex 35 Neisseria meningitidis isolates used in investigation of antimicrobial-resistant clonal complex 11 N. meningitidis–associated urethritis cluster, Thailand. The tree is based on 65 core-genome single-nucleotide polymorphisms of isolates collected from multiple disease types. Red dot indicates the single N. meningitidis–associated urethritis isolate (NM4) from this study. Scale bar indicates nucleotide substitutions per site. NA, not available.
See this image and copyright information in PMC

References

    1. Christensen H, May M, Bowen L, Hickman M, Trotter CL. Meningococcal carriage by age: a systematic review and meta-analysis. Lancet Infect Dis. 2010;10:853–61. 10.1016/S1473-3099(10)70251-6 - DOI - PubMed
    1. Bazan JA, Peterson AS, Kirkcaldy RD, Briere EC, Maierhofer C, Turner AN, et al. Notes from the field: increase in Neisseria meningitidis–associated urethritis among men at two sentinel clinics—Columbus, Ohio, and Oakland County, Michigan, 2015. MMWR Morb Mortal Wkly Rep. 2016;65:550–2. 10.15585/mmwr.mm6521a5 - DOI - PMC - PubMed
    1. Retchless AC, Kretz CB, Chang HY, Bazan JA, Abrams AJ, Norris Turner A, et al. Expansion of a urethritis-associated Neisseria meningitidis clade in the United States with concurrent acquisition of N. gonorrhoeae alleles. BMC Genomics. 2018;19:176. 10.1186/s12864-018-4560-x - DOI - PMC - PubMed
    1. Brooks A, Lucidarme J, Campbell H, Campbell L, Fifer H, Gray S, et al. Detection of the United States Neisseria meningitidis urethritis clade in the United Kingdom, August and December 2019 - emergence of multiple antibiotic resistance calls for vigilance. Euro Surveill. 2020;25:2000375. 10.2807/1560-7917.ES.2020.25.15.2000375 - DOI - PMC - PubMed
    1. Nguyen HT, Phan TV, Tran HP, Vu TTP, Pham NTU, Nguyen TTT, et al. Outbreak of sexually transmitted nongroupable Neisseria meningitidis–associated urethritis, Vietnam. Emerg Infect Dis. 2023;29:2130–4. 10.3201/eid2910.221596 - DOI - PMC - PubMed

MeSH terms

Substances

LinkOut - more resources