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. 2025 Nov 17;10(12):3369-3375.
doi: 10.1039/d5nh00468c.

Light-triggered quenching of the 19F-MRI signal from micelle-encapsulated PERFECTA

Claire Leterrier  1 , Guillaume Pinna  2   3 , Marie Vandamme  2   3 , Mélissa Glatigny  4 , Erwan Selingue  4 , Françoise Geffroy  4 , Sébastien Mériaux  4 , Edmond Gravel  1 , Eric Doris  1
Affiliations

Light-triggered quenching of the 19F-MRI signal from micelle-encapsulated PERFECTA

Claire Leterrier et al. Nanoscale Horiz. .

Abstract

We report the development of a fluorinated micellar nanosystem whose 19F-MRI signal can be selectively dimmed by application of an external stimulus. A photo-activatable quencher unit (ferrocene) was co-encapsulated with the superfluorinated PERFECTA probe in colloidal micelles. While pristine micelles were MRI responsive ("On" state), their irradiation by light triggered the "Off" MRI-state of PERFECTA.

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