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Comment
. 2025 Sep 12:16:1624011.
doi: 10.3389/fimmu.2025.1624011. eCollection 2025.

Commentary: Long COVID in pediatric age: an observational, prospective, longitudinal, multicenter study in Italy

Cristiana Indolfi #  1 , Angela Klain #  1 , Giulio Dinardo  1 , Carolina Grella  1 , Maria Maddalena Marrapodi  1 , Michele Miraglia Del Giudice  1
Affiliations
Comment

Commentary: Long COVID in pediatric age: an observational, prospective, longitudinal, multicenter study in Italy

Cristiana Indolfi et al. Front Immunol. .
No abstract available

Keywords: children; follow-up protocol; long COVID; lung ultrasound; neuropsychological symptoms.

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Conflict of interest statement

The declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision.

Figures

Figure 1
Figure 1
The figure illustrates the long COVID follow-up conducted at our Pediatric Clinic at the University of Campania “Luigi Vanvitelli” in Naples, Italy. We collected detailed medical histories, including SARS-CoV-2-related manifestations, conducted clinical examinations, a 6-minute walking test, spirometry, lung ultrasound (LUS), and a neuropsychological evaluation. Our findings confirmed that the most common long COVID symptoms in the pediatric population involve neuropsychological aspects and pulmonary manifestations. In particular, obesity was significantly associated with both the severity of the acute phase of the disease and the presence of LUS abnormalities. We also observed an increase in behavioral and sleep disturbances, especially among adolescents, with a broader impact on their physical and emotional well-being. These findings highlight the need for long-term, in-depth follow-up over the coming years. Figure created in https://BioRender.com.
See this image and copyright information in PMC

Comment on

  • Long COVID in pediatric age: an observational, prospective, longitudinal, multicenter study in Italy.
    Esposito S, Puntoni M, Deolmi M, Ramundo G, Maglietta G, Poeta M, Zampogna S, Colomba C, Suppiej A, Cardinale F, Bosis S, Castagnola E, Midulla F, Giaquinto C, Giordano P, Biasucci G, Fainardi V, Nunziata F, Grandinetti R, Condemi A, Raiola G, Guarino A, Caminiti C; Long-Covid-Ped Italian Study Group. Esposito S, et al. Front Immunol. 2025 Apr 9;16:1466201. doi: 10.3389/fimmu.2025.1466201. eCollection 2025. Front Immunol. 2025. PMID: 40270969 Free PMC article.

References

    1. Sposito S, Puntoni M, Deolmi M, Ramundo G, Maglietta G, Poeta M, et al. Long COVID in pediatric age: an observational, prospective, longitudinal, multicenter study in Italy. Front Immunol. (2025) 16:1466201. doi: 10.3389/fimmu.2025.1466201, PMID: - DOI - PMC - PubMed
    1. Indolfi C, Klain A, Dinardo G, D’Addio E, Ferrara S, Decimo F, et al. COVID-19 pediatric follow-up: respiratory long COVID-associated comorbidities and lung ultrasound alterations in a cohort of Italian children. Children (Basel). (2024) 11:166. doi: 10.3390/children11020166, PMID: - DOI - PMC - PubMed
    1. Miraglia Del Giudice M, Klain A, Dinardo G, D'Addio E, Bencivenga CL, Fontanella C, et al. Behavioral and sleep disorders in children and adolescents following COVID-19 disease: a case-control study. Children (Basel). (2023) 10:1189. doi: 10.3390/children10071189, PMID: - DOI - PMC - PubMed
    1. Premraj L, Kannapadi NV, Briggs J, Seal SM, Battaglini D, Fanning J, et al. Mid and long-term neurological and neuropsychiatric manifestations of post-COVID-19 syndrome: a meta-analysis. J Neurol Sci. (2022) 434:120162. doi: 10.1016/j.jns.2022.120162, PMID: - DOI - PMC - PubMed
    1. Kubota T, Kuroda N, Sone D. Neuropsychiatric aspects of long COVID: a comprehensive review. Psychiatry Clin Neurosci. (2023) 77:84–93. doi: 10.1111/pcn.13508, PMID: - DOI - PMC - PubMed

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