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. 2025 Sep 29;7(1):72.
doi: 10.1186/s42238-025-00333-4.

ABCB1 polymorphisms are associated with clinical response to nabiximols in patients with multiple sclerosis-related spasticity

Alessandra Gemma  1 , Marco Mauri  2   3 , Paola Banfi  2 , Maurizio Versino  2 , Alen Zollo  4 , Filippo Martinelli Boneschi  4   5 , Franca Marino  1 , Marco Cosentino  1 , Marco Ferrari  6
Affiliations

ABCB1 polymorphisms are associated with clinical response to nabiximols in patients with multiple sclerosis-related spasticity

Alessandra Gemma et al. J Cannabis Res. .
No abstract available

Keywords: ABCB1; Multiple sclerosis; Nabiximols; Single nucleotide polymorphisms; Spasticity.

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Conflict of interest statement

Declarations. Ethics approval and consent to participate: All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional committee (ASST Sette Laghi Hospital, Varese, Italy on February 21, 2023 - Study number 164) and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants included in the study prior to their inclusion in the study. Competing interests: The authors declare no competing interests. Additional information: The Authors wish to dedicate this study to the loving memory of Paola Banfi, dearest friend, caring physician, and invaluable scientist.

Figures

Fig. 1
Fig. 1
Relationship between SNPs ABCB1 and % of reduction in NRS score. § = P < 0.05 C/T vs. C/C; §§ = P < 0.01 T/T vs. C/C; *** = P < 0.0001 T/T vs. A/A; ### = P < 0.0001 T/T vs. A/T
See this image and copyright information in PMC

References

    1. Almog S, Aharon-Peretz J, Vulfsons S, Ogintz M, Abalia H, Lupo T, Hayon Y, Eisenberg E. The pharmacokinetics, efficacy, and safety of a novel selective-dose cannabis inhaler in patients with chronic pain: a randomized, double-blinded, placebo-controlled trial. Eur J Pain. 2020;24:1505–16. 10.1002/ejp.1605 - PMC - PubMed
    1. Babayeva M, Loewy ZG. Cannabis pharmacogenomics: a path to personalized medicine. Curr Issues Mol Biol. 2023;45:3479–514. 10.3390/cimb45040228 - PMC - PubMed
    1. Batinic A, Sutlović D, Kuret S, Matana A, Kumric M, Bozic J, Dujic Z. Trial of a novel oral cannabinoid formulation in patients with hypertension: a double-blind, placebo-controlled pharmacogenetic study. Pharmaceuticals (Basel). 2023;16:645. 10.3390/ph16050645 - PMC - PubMed
    1. Brambila-Tapia AJ. MDR1 (ABCB1) polymorphisms: functional effects and clinical implications. Rev Investig Clin. 2013;65:445–54. - PubMed
    1. Chan A, Silván CV. Evidence-based management of multiple sclerosis spasticity with nabiximols oromucosal spray in clinical practice: a 10-year recap. Neurodegener Dis Manag. 2022;12(3):141–54. 10.2217/nmt-2022-0002 - PubMed

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