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. 2025 Oct 1.
doi: 10.1111/cge.70078. Online ahead of print.

Reduced Penetrance and Variable Expression of Dilated Cardiomyopathy Associated With Homozygous Truncating Variants in NRAP Gene

Aisha Alqahtani  1   2 , Sahar Tulbah  1 , Nadiah Alruwaili  3 , Saud Takroni  1   4 , Maarab Alkorashy  1 , Waleed Manea  3 , Dimpna C Albert Brotons  3 , Abdullah Alwadai  5 , Jehad Alburaiki  3 , Fowzan Alkuraya  6 , Nadiah Al-Hashmi  7 , Samah Zarroug  2 , Zuhair N Al-Hassnan  1   2   4
Affiliations

Reduced Penetrance and Variable Expression of Dilated Cardiomyopathy Associated With Homozygous Truncating Variants in NRAP Gene

Aisha Alqahtani et al. Clin Genet. .

Abstract

Dilated Cardiomyopathy (DCM) is a genetically heterogeneous condition of left ventricular dilation and systolic dysfunction, leading to heart failure. It is mostly inherited in a dominant pattern. Recessive inheritance has been rarely encountered. This study aims to outline the clinical and genetic characteristics associated with recessively inherited NRAP truncating variants in our highly consanguineous population. Twenty-three cases from 12 unrelated consanguineous families were recruited. Cardiological evaluation and genetic testing with exome sequencing (ES) were conducted in all cases, followed by segregation analysis of first-degree relatives. Genetic analysis with ES identified five unique homozygous truncating variants in NRAP in the affected cases. The segregation analysis detected a total of 23 homozygous and 21 heterozygous individuals. Out of the total homozygous cases, three were asymptomatic, while 20 exhibited symptoms with remarkable inter- and intrafamilial variability of the age of onset (range: 9 months to 47 years, median 10 years), seven of whom died (range: 9 months to 28 years, median 7 years). None of the heterozygous individuals showed symptoms. Of note, three homozygous cases underwent heart transplantation. Our findings show that truncating variants in NRAP are associated with reduced penetrance and clinical variability, suggesting a complex mechanism beyond simple Mendelian inheritance.

Keywords: NRAP; dilated cardiomyopathy; reduced penetrance.

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