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. 2025 Oct 1;29(1):415.
doi: 10.1186/s13054-025-05655-6.

Conventional versus pump-controlled retrograde trial off (PCRTO) weaning in V-A ECMO: exploring feasibility, physiological insights and benefits

Affiliations

Conventional versus pump-controlled retrograde trial off (PCRTO) weaning in V-A ECMO: exploring feasibility, physiological insights and benefits

Francesca Fiorelli et al. Crit Care. .
No abstract available

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Conflict of interest statement

Declarations. Ethics approval and consent to participate: This study was registered as a service evaluation on each of the sites. As per local agreement, informed consent could be waived. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Schematic overview indicating the flow during conventional peripheral V-A ECMO-support (left panel) and flow reversal during PCRTO (right panel). RV: right ventricle; LV: left ventricle; V-A ECMO: veno-arterial extracorporeal membrane oxygenation; PCRTO: pump-controlled retrograde trial off; rpm: revolution per minute; MAP: mean arterial pressure; P-return ECMO: return ECMO-cannula pressure

References

    1. Brahmbhatt DH, Daly AL, Luk AC, Fan E, Billia F. Liberation from venoarterial extracorporeal membrane oxygenation: a review. Circ Heart Fail. 2021;14(7):e007679. - PubMed
    1. Westrope C, Harvey C, Robinson S, Speggiorin S, Faulkner G, Peek GJ. Pump controlled retrograde trial off from VA-ECMO. ASAIO J. 2013;59(5):517–9. - PubMed
    1. Pandya NR, Daley M, Mattke A, Shikata F, Betts K, Haisz E, et al. A comparison of pump-controlled retrograde trial off to arterio-venous bridging for weaning from venoarterial extracorporeal membrane oxygenation. Eur J Cardiothorac Surg. 2019. 10.1093/ejcts/ezy485. - PubMed
    1. Ling L, Chan KM. Weaning adult patients with cardiogenic shock on veno-arterial extracorporeal membrane oxygenation by pump-controlled retrograde trial off. Perfusion. 2018;33(5):339–45. - PubMed
    1. Randhawa VK, Al-Fares A, Tong MZY, Soltesz EG, Hernandez-Montfort J, Taimeh Z, et al. A pragmatic approach to weaning temporary mechanical circulatory support: a state-of-the-art review. JACC Heart Fail. 2021;9(9):664–73. - PubMed

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