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Review
. 2025 Sep 16:13:1608923.
doi: 10.3389/fbioe.2025.1608923. eCollection 2025.

Advances in tissue engineering for the repair of growth plate injuries

Wenla Wang  1   2 , Wenxiang Zeng  1   2 , Qingyu Tu  1   2 , Qing Li  1   2 , Jindi Xu  1   2 , Wei Zhuang  1   2
Affiliations
Review

Advances in tissue engineering for the repair of growth plate injuries

Wenla Wang et al. Front Bioeng Biotechnol. .

Abstract

The growth plate is a cartilage tissue located between the epiphysis and diaphysis of long bones, responsible for the longitudinal growth of the skeleton. Due to its limited regenerative capacity, when the growth plate is damaged, it is typically replaced by inappropriate bone tissue, leading to the formation of bony bridges. These bony bridges not only restrict normal skeletal growth but may also cause limb length discrepancies, angular deformities, and functional impairments. Although traditional clinical treatments have shown some effectiveness, they are often associated with severe complications and poor prognoses. Therefore, the development of effective therapeutic strategies to prevent the formation of bony bridges and promote the repair and regeneration of the growth plate has become a current research focus. Cartilage tissue engineering, as an emerging therapeutic approach, restore the function of the growth plate through the substitution or repair of damaged cartilage tissue, has been widely applied in the repair of growth plate injuries. Cartilage tissue engineering for growth plate injury primarily relies on three key components: seed cells, growth factors, and scaffold materials. Seed cells provide the basis for cartilage regeneration, typically using autologous or allogeneic chondrocytes, mesenchymal stem cells, etc.,; growth factors such as bone morphogenetic proteins (BMPs) and transforming growth factor-beta (TGF-β) promote cell proliferation and differentiation, while regulating the synthesis of cartilage matrix; scaffold materials provide three-dimensional structural support, offering a platform for directed cell growth and tissue repair. In recent years, with continuous advancements in biomaterials and innovations in tissue engineering techniques, cartilage tissue engineering has shown promising prospects for application. This article systematically reviews the latest research progress on cartilage tissue engineering in the repair of growth plate injuries, based on a comprehensive search and analysis of relevant literature from databases such as PubMed and CNKI. The paper focuses on the classification and stages of growth plate injuries and discusses the three essential elements of tissue engineering treatment for growth plate injury.

Keywords: 3D printing technology; growth factors; growth plate injury; scaffold material; seed cells; tissue engineering.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Type of growth plate injury.
FIGURE 2
FIGURE 2
Growth plate injury and application of tissue engineering.
FIGURE 3
FIGURE 3
Four stages of Growth Plate Injury.
FIGURE 4
FIGURE 4
Tissue Engineering treatment for Growth Plate Injury. (1) Scaffold made of natural materials and composite materials. (2) Scaffold made by 3D printing technology.
FIGURE 5
FIGURE 5
The Three Elements of Organizational Engineering. (A) The frequency and influence of the cells. (B) The frequency and influence of the growth factors. (C) The frequency and influence of the biomaterials.
See this image and copyright information in PMC

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