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. 2025 Oct 3;6(1):70.
doi: 10.1186/s43556-025-00288-1.

Adipose-Derived Stem Cell Therapy Attenuates HIF-1α/mTOR/REDD1 Signaling in Obese Hypertensive Rats

Renata Nakamichi  1 , Mario Luis Ribeiro Cesaretti  1 , Eric Rafael Andrade Silva  1 , Camila Nunes Oliveira  1 , Evelyn Manuella Martins Gomes Jodas  1 , Miguel Cendoroglo Neto  2 , Beata Marie Redublo Quinto  3 , Marcelo Costa Batista  1   2
Affiliations

Adipose-Derived Stem Cell Therapy Attenuates HIF-1α/mTOR/REDD1 Signaling in Obese Hypertensive Rats

Renata Nakamichi et al. Mol Biomed. .
No abstract available

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Conflict of interest statement

Declarations. Ethics approval and consent to participate: The study protocol was approved by the Ethics Committee for the Use of Animals at UNIFESP (CEUA No. 1167250414). Consent for publication: Not applicable, as no personal data or identifiable images were included in this study. Competing interests: The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Effects of adipose-derived stem cell (ASC) treatment on visceral fat, HIF-1α expression, and the mTOR/REDD1 pathway in spontaneously hypertensive rats (SHRs) with high-fat diet-induced obesity. (a) Plasma concentration of HIF-1α (top) and mRNA expression of HIF-1α in epididymal adipose tissue (bottom). (b) tissue mTOR mRNA expression in kidney tissue. (c) HIF-1α mRNA expression in kidney. (d) Western blot analysis of REDD1, HIF-1α, and mTOR protein expression in kidney tissue. ASC treatment significantly reduced both gene and protein expression of HIF-1α, REDD1, and mTOR in animals fed a high-fat diet, suggesting attenuation of hypoxia and inflammatory pathways. Data are presented as mean ± SEM (n = 6 per group). *p < 0.05 vs. Control; •p < 0.05 vs. HD. Bar color legend: Black = Control; Blue = HD (high-fat diet); Purple = CT + ASC1; Yellow = CT + ASC2; Gray = HD + ASC1; Orange = HD + ASC2
See this image and copyright information in PMC

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