Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2025 Aug 18;4(9):103866.
doi: 10.1016/j.jscai.2025.103866. eCollection 2025 Sep.

SCAI Position Statement on Transcatheter Occlusion of Patent Ductus Arteriosus in Premature Infants

Sarosh P Batlivala  1 , Dana Boucek  2 , Tacy Downing  3 , Timothy Head  4 , Carrie Herbert  5 , Philip Levy  6 , R Allen Ligon  7 , Souvik Mitra  8 , Arash Salavitabar  9 , Shyam Sathanandam  10 , Nathaniel Taggart  11 , Jenny Zablah  12 , Evan Zahn  13 , Brent M Gordon  14
Affiliations

SCAI Position Statement on Transcatheter Occlusion of Patent Ductus Arteriosus in Premature Infants

Sarosh P Batlivala et al. J Soc Cardiovasc Angiogr Interv. .

Abstract

Historically, pharmacotherapy and surgical ligation have been the primary treatments for occlusion of patent ductus arteriosus (PDA), but recent advancements have led to the US Food and Drug Administration approval of the first transcatheter PDA occlusion device for low birth weight infants in 2019. Although short-term outcomes have been encouraging, successful outcomes are highly dependent on proper patient selection, awareness of key procedural considerations, appropriately trained operators, and institutions meeting a standard of required infrastructural requirements. A multidisciplinary approach involving neonatologists and cardiologists is beneficial, as well as shared decision-making with the patient's family. This position statement from the Society for Cardiovascular Angiography & Interventions provides comprehensive suggestions to optimize the safety and efficacy of transcatheter PDA occlusion in premature infants, aiming to improve long-term outcomes in this vulnerable population.

Keywords: congenital interventional cardiology; premature patent ductus arteriosus occlusion.

PubMed Disclaimer

Conflict of interest statement

Tacy Downing is a site principal investigator for the COMPASS Trial. Allen Ligon is a proctor for Abbott. Shyam Sathanandam is a consultant, advisor, and speaker for Abbott and is a principal investigator for the US PDA Registry, which is funded by Abbott. He is also a principal investigator for a preclinical trial sponsored by Medtronic. Nathaniel Taggart is a coinvestigator on the Harmony TPV trial sponsored by Medtronic. Jenny Zablah is a consultant for Medtronic and a principal investigator for a clinical trial on OCT in pulmonary vein stenosis sponsored by Abbott. Brent M. Gordon is a proctor and consultant for Abbott and Merit Medical. The other authors reported no financial interests.

Figures

Figure 1
Figure 1
Transcatheter patent ductus arteriosus occlusion procedure checklist. ABG, arterial blood gas; BP, blood pressure; CBC, complete blood count; CXR, chest x-ray; NG, nasogastric; NICU, neonatal intensive care unit; SCAI, Society for Cardiovascular Angiography & Interventions; SBE, spontaneous bacterial endocarditis; tcPDA, transcatheter patent ductus arteriosus; VBG, venous blood gas.
Figure 2
Figure 2
Profiles of three commonly utilized tcPDA occlusion devices. (A) Amplatzer Piccolo Occluder (Abbott), (B) MVP micro vascular plug system (Medtronic), and (C) Micro Plug Set (Merit Medical Systems).
Figure 3
Figure 3
Key angiographic markers during tcPDA occlusion procedures. (A) Angiogram in straight lateral projection of patent ductus arteriosus (PDA). Note the temperature probe (∗), which marks the posterior portion of the PDA as it meets the aorta and the upper extremity peripherally inserted central catheter line (#) that demarcates the anterior portion of the PDA. Repeat angiogram after PDA device implantation but before release in (B) anterior left anterior oblique projection and (C) straight lateral projection. Note that the device sits anterior to the temperature probe (∗) and posterior to the peripherally inserted central catheter line with unobstructed flow into the left pulmonary artery (arrow). Importantly, the device is slightly elongated and constrained by the PDA, suggesting that it is stable and well-sized.
See this image and copyright information in PMC

References

    1. Parkerson S., Philip R., Talati A., Sathanandam S. Management of patent ductus arteriosus in premature infants in 2020. Front Pediatr. 2021;8 doi: 10.3389/fped.2020.590578. - DOI - PMC - PubMed
    1. Noori S., McCoy M., Friedlich P., et al. Failure of ductus arteriosus closure is associated with increased mortality in preterm infants. Pediatrics. 2009;123(1):e138–e144. doi: 10.1542/peds.2008-2418. - DOI - PubMed
    1. Hamrick S.E.G., Sallmon H., Rose A.T., et al. Patent ductus arteriosus of the preterm infant. Pediatrics. 2020;146(5) doi: 10.1542/peds.2020-1209. - DOI - PMC - PubMed
    1. Marconi E., Bettiol A., Ambrosio G., et al. Efficacy and safety of pharmacological treatments for patent ductus arteriosus closure: a systematic review and network meta-analysis of clinical trials and observational studies. Pharmacol Res. 2019;148 doi: 10.1016/j.phrs.2019.104418. - DOI - PubMed
    1. Heymann M.A., Rudolph A.M., Silverman N.H. Closure of the ductus arteriosus in premature infants by inhibition of prostaglandin synthesis. N Engl J Med. 1976;295(10):530–533. doi: 10.1056/NEJM197609022951004. - DOI - PubMed

LinkOut - more resources