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. 2025 Oct 2;32(10):1481-1482.
doi: 10.1016/j.stem.2025.08.008.

Unmasking cancer's hidden nerve route with patient-derived organoids

Kevin M Waters  1 , Akil Merchant  2 , De-Chen Lin  3
Affiliations

Unmasking cancer's hidden nerve route with patient-derived organoids

Kevin M Waters et al. Cell Stem Cell. .

Abstract

Chan et al.1 show that enteric neurons influence lipid metabolism in gastric cancer organoids, affecting dependencies on key enzymes. Using CRISPR screening and metabolic analysis, their work highlights how microenvironmental signals impact tumor metabolism and potential treatment targets in gastric cancer.

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Conflict of interest statement

Declaration of interests The authors declare no potential conflicts of interest.

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