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. 1971 Sep;21(3):517-25.

The formation of antigenic polymers in aqueous solutions of -lactam antibiotics

J M Dewdney, H Smith, A W Wheeler

The formation of antigenic polymers in aqueous solutions of -lactam antibiotics

J M Dewdney et al. Immunology. 1971 Sep.

Abstract

Samples from concentrated aqueous solutions of β-lactam antibiotics were examined by gel filtration. The eluates were monitored by ultraviolet (uv) absorption and by passive cutaneous anaphylaxis (PCA) in guinea-pigs sensitized with appropriate antiserum raised in rabbits. The appearance of uv absorbing material, giving a positive PCA reaction, in fractions from the high molecular weight regions of the eluates from gel filtration of aged solutions was taken as evidence of antigenic polymer formation.

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References

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