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Review
. 2025 Oct 7:1-16.
doi: 10.1080/02713683.2025.2566853. Online ahead of print.

Corneal Sealants in Pre-Clinical Development

Jackie Tan  1 , Leslie John Ray Foster  1   2 , Frank James Lovicu  1 , Yogambha Ramaswamy  1 , Gurvinder Singh  1 , Stephanie Louise Watson  1
Affiliations
Free article
Review

Corneal Sealants in Pre-Clinical Development

Jackie Tan et al. Curr Eye Res. .
Free article

Abstract

Purpose: To examine corneal sealants and adhesives in the pre-clinical phase of development to guide future development.

Method: A systematic review of major databases from inception to 4th March 2025.

Results: Corneal sealants and adhesives can be broadly divided into biological and synthetic groups. These are further categorized by their methods of adhesion activation. This review identified the following groups: human fibrin glue, cyanoacrylates, biodendrimers, polyethylene glycol, fibrinogen, albumin, collagen, gelatin, chondroitin, hyaluronic acid, dextran, and chitosan. Burst pressures are often reported as a measure of sealing efficacy. Ideal characteristics for future development include biocompatibility, tolerate high burst pressure, on-demand activation, accelerates healing, and does no transmit infection.

Conclusion: A variety of corneal sealants and adhesives are in development. To seal corneal wounds sealants and adhesive should have a range of properties to prevent leak.

Keywords: Cornea; adhesive; glue; patch; sealant.

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