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. 1971 Aug 20;173(3998):743-5.
doi: 10.1126/science.173.3998.743.

Histamine augments leukocyte adenosine 3',5'-monophosphate and blocks antigenic histamine release

Histamine augments leukocyte adenosine 3',5'-monophosphate and blocks antigenic histamine release

H R Bourne et al. Science. .

Abstract

Extracellular histamine stimulates accumulation of adenosine 3',5'-monophosphate in human leukocytes and prevents antigenic release of histamine from cells of allergic donors. Both effects occur at histamine concentrations that can be achieved by antigenic release of the amine in vitro.

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