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. 2025 Sep 22:6:1641312.
doi: 10.3389/falgy.2025.1641312. eCollection 2025.

Use of a digital rescue inhaler and at-home spirometer among inner-city children with asthma: a real-world experience

Neema Izadi  1 , Tanisha D Hill  2 , Amanda Boe  2 , Daisy Yu  2 , Jonathan S Tam  1
Affiliations

Use of a digital rescue inhaler and at-home spirometer among inner-city children with asthma: a real-world experience

Neema Izadi et al. Front Allergy. .

Abstract

Background: Across all age groups, asthma disproportionally affects inner-city underserved populations. Studies on the use of at-home spirometry and digital inhalers have limited real-world evaluation in pediatric asthma.

Objectives: In this prospective exploratory study, we assessed how an integrated digital rescue inhaler and at-home spirometer would affect proper inhaler use, medication adherence, and asthma outcomes using a minimalistic real-world approach.

Methods: In total, 21 pediatric patients with asthma (8-17 years of age) were asked to replace rescue medications with the ProAir Digihaler and perform at-home gamified spirometry daily. Lung function and questionnaires were obtained at baseline and at 3-4 months.

Results: The participants were mostly male (81%), Latino/Hispanic (71%), and obese (88th ±16 percentile). Proper rescue inhaler step identification by survey did not change, but inhalation technique based on digital inhaler flow measurements improved for all participants. At-home spirometry was sporadic and reported controller adherence did not change. Younger children (age 8-11) were more severe at baseline [Composite Asthma Severity Index (CASI) of 4.8] compared to older children (CASI of 2.9). For younger children, overall asthma control test scores increased by 3.1, CASI decreased by 0.70, and the Pediatric Quality of Life Inventory scores increased by 14 and 11 for participants and parents, respectively.

Conclusions: Proper rescue inhaler step identification by survey did not change, but actual inhalation technique based on digital inhaler flow measurements improved. At-home spirometry was sporadic and reported medication adherence did not change. Younger children used the spirometer more frequently and demonstrated improvements in asthma control, severity, and quality of life. These improvements were not observed in older children.

Keywords: adherence; asthma; digital inhaler; inner-city; pediatrics; rescue inhaler; spirometry; underserved.

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Conflict of interest statement

TH, AB, and DY were employed by Teva Branded Pharmaceutical Products R&D, Inc. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision.

Figures

Figure 1
Figure 1
Quality of Digihaler rescue inhalations over time.
See this image and copyright information in PMC

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