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. 2025 Jun 4;31(2):e2346.
doi: 10.7196/AJTCCM.2025.v31i2.2346. eCollection 2025.

Perinatal transmission and cure of extensively drug-resistant tuberculosis in an infant

V Singh  1   2 , R Perumal  3   4   5 , M Wessels  6 , F Hai  7 , K Lutchminarain  1   2 , K Naidoo  3   4 , K Swe Swe-Han  1   2
Affiliations

Perinatal transmission and cure of extensively drug-resistant tuberculosis in an infant

V Singh et al. Afr J Thorac Crit Care Med. .

Abstract

We describe a rare case of perinatally acquired extensively drug-resistant tuberculosis in an infant. The infant was successfully treated with an individualised all-oral multidrug regimen containing delamanid, a drug rarely described in the treatment of perinatal tuberculosis. What the study adds. This brief report offers insight into a clinical case of perinatally acquired extensively drug-resistant tuberculosis (XDR-TB), and outlines the individualised treatment plan that led to a successful treatment outcome. Implications of the findings. The report highlights the need for evidence-based guidance on XDR-TB in this paediatric population, as well as further research on preventive strategies for mitigating mother-to-child transmission of TB.

Keywords: Drug-resistant tuberculosis; perinatal tuberculosis.

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