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Review
. 2025 Oct 8.
doi: 10.1007/s13555-025-01536-6. Online ahead of print.

Dermatologic Comorbidities Associated with Atopic Dermatitis Towards a Shared Therapeutical Approach: A Narrative Review

Maria Esposito #  1 , Alessandro Giunta #  2 , Andrea De Berardinis  1 , Lina Maria Magnanimi  3 , Maria Concetta Fargnoli  1 , Cataldo Patruno  4 , Luca Potestio #  5 , Maddalena Napolitano #  5
Affiliations
Review

Dermatologic Comorbidities Associated with Atopic Dermatitis Towards a Shared Therapeutical Approach: A Narrative Review

Maria Esposito et al. Dermatol Ther (Heidelb). .

Abstract

Introduction: Atopic dermatitis (AD) is a chronic inflammatory skin condition commonly associated with other dermatologic comorbidities, which can complicate management and affect treatment outcomes. This review aims to analyse the dermatologic comorbidities of AD, their underlying mechanisms, and therapeutic implications, with a focus on their management in clinical practice.

Methods: A narrative review was conducted by searching PubMed, Embase, Cochrane and ClinicalTrials.gov, using terms related to AD and its comorbidities, including allergic contact dermatitis, alopecia areata, prurigo nodularis, psoriasis, hidradenitis suppurativa and chronic spontaneous urticaria.

Results: The literature highlights a strong association between AD and several dermatologic comorbidities, including allergic contact dermatitis, alopecia areata, chronic spontaneous urticaria, hidradenitis suppurativa, psoriasis, prurigo nodularis and vitiligo. Promising therapeutic effects were observed with JAK inhibitors, dupilumab and other biologics across multiple comorbid condition.

Conclusion: Recognizing comorbidities in AD is critical for effective management. Tailored therapies targeting both AD and its comorbidities, based on shared immunological mechanisms, may improve outcomes. Further research is needed to optimize treatment strategies and explore combination therapies for patients with both AD and comorbid dermatological conditions.

Keywords: Atopic dermatitis; Biologic treatment; Comorbidities; Small molecules.

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Conflict of interest statement

Declarations. Conflict of interest: Maria Esposito has served as speaker/consultant for Abbvie, Amgen, Almirall, Boehringer Ingelheim, Eli Lilly, Janssen, Leopharma, Novartis, Pfizer, Sanofi Regeneron and UCB. Alessandro Giunta has served as speaker/consultant for Abbvie, Boehringer-Ingelheim, Eli Lilly, Novartis, Sandoz and UCB. Maria Concetta Fargnoli has served on advisory boards, received honoraria for lectures and/or research grants from AMGEN, Almirall, Abbvie, Boehringer-Ingelheim, BMS, Galderma, Kyowa Kyrin, Leo Pharma, Pierre Fabre, UCB, Lilly, Pfizer, Janssen, MSD, Novartis, Sanofi-Regeneron and Sunpharma. Cataldo Patruno has acted as speaker, consultant and/or advisory board member AbbVie, Almirall, Amgen, Galderma, Leo Pharma, Lilly, Novartis, Pfizer, Pierre Fabre and Sanofi. Maddalena Napolitano has acted as speaker, consultant and/or advisory board member for Abbvie, Eli Lilly, Leo Pharma, Novartis, Incyte and Sanofi. Andrea De Berardinis, Luca Potestio and Lina Maria Magnanimi have nothing to disclose. Ethical Approval: This article is based on previously conducted studies and does not contain any new studies with human participants or animals performed by any of the authors.

References

    1. Ständer S. Atopic dermatitis. N Engl J Med. 2021;384(12):1136–43. - PubMed - DOI
    1. Asher MI, Montefort S, Björkstén B, et al. Worldwide time trends in the prevalence of symptoms of asthma, allergic rhino conjunctivitis, and eczema in childhood: ISAAC phases one and three repeat multicounty cross-sectional surveys. Lancet. 2006;368:733–43. - PubMed - DOI
    1. Nutten S. Atopic dermatitis: global epidemiology and risk factors. Ann Nutr Metab. 2015;66(Suppl 1):8–16. - PubMed - DOI
    1. Thyssen JP, Halling AS, Schmid-Grendelmeier P, Guttman-Yassky E, Silverberg JI. Comorbidities of atopic dermatitis-what does the evidence say? J Allergy Clin Immunol. 2023;151(5):1155–62. - PubMed - DOI
    1. Dhingra N, Shemer A, da Rosa JC, Rozenblit M, Fuentes-Duculan J, Gittler JK, et al. Molecular profiling of contact dermatitis skin identifies allergen-dependent differences in immune response. J Allergy Clin Immunol. 2014;134(2):362–72. - PubMed - DOI

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