Corrigendum to 'Blocking Kv1.3 potassium channels prevents postoperative neuroinflammation and cognitive decline without impairing wound healing in mice' (Br J Anaesth 2020; 125: 298-307)

Ieng K Lai¹, Martin Valdearcos², Kazuhito Morioka³, Sarah Saxena⁴, Xiaomei Feng⁵, Rong Li⁶, Yosuke Uchida⁷, An Lijun⁸, Wei Li⁹, Jonathan Pan¹⁰, Suneil Koliwad², Ralph Marcucio³, Heike Wulff¹¹, Mervyn Maze¹²

Affiliations

¹ Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA, USA.
² Diabetes Center and Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
³ Orthopaedic Trauma Institute, Department of Orthopaedic Surgery, University of California, San Francisco, San Francisco, CA, USA.
⁴ Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA, USA; Department of Anesthesia, University Hospital Center CHU-Charleroi, Charleroi, Belgium.
⁵ Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA, USA; Department of Anesthesiology, University of Utah, Salt Lake City, UT, USA.
⁶ Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA, USA; Department of Anesthesiology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
⁷ Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA, USA; Department of Anesthesiology and Critical Care Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
⁸ Weill Institute for Neurosciences, Brain and Spinal Injury Center (BASIC), Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA; Department of Anesthesiology, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, Huaian, China.
⁹ Weill Institute for Neurosciences, Brain and Spinal Injury Center (BASIC), Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA; Department of Anesthesia, Shandong Provincial Hospital, Jinan, China.
¹⁰ Weill Institute for Neurosciences, Brain and Spinal Injury Center (BASIC), Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
¹¹ Department of Pharmacology, University of California, Davis, Davis, CA, USA.
¹² Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA, USA. Electronic address: Mervyn.Maze@UCSF.edu.

PMID: 41062364
PMCID: PMC12799455 (available on 2026-12-01)
DOI: 10.1016/j.bja.2025.09.003

Published Erratum

Corrigendum to 'Blocking Kv1.3 potassium channels prevents postoperative neuroinflammation and cognitive decline without impairing wound healing in mice' (Br J Anaesth 2020; 125: 298-307)

Ieng K Lai et al. Br J Anaesth. 2025 Dec.

. 2025 Dec;135(6):1903-1904.

doi: 10.1016/j.bja.2025.09.003. Epub 2025 Oct 7.

Authors

Affiliations

¹ Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA, USA.
² Diabetes Center and Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
³ Orthopaedic Trauma Institute, Department of Orthopaedic Surgery, University of California, San Francisco, San Francisco, CA, USA.
⁴ Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA, USA; Department of Anesthesia, University Hospital Center CHU-Charleroi, Charleroi, Belgium.
⁵ Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA, USA; Department of Anesthesiology, University of Utah, Salt Lake City, UT, USA.
⁶ Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA, USA; Department of Anesthesiology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
⁷ Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA, USA; Department of Anesthesiology and Critical Care Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
⁸ Weill Institute for Neurosciences, Brain and Spinal Injury Center (BASIC), Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA; Department of Anesthesiology, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, Huaian, China.
⁹ Weill Institute for Neurosciences, Brain and Spinal Injury Center (BASIC), Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA; Department of Anesthesia, Shandong Provincial Hospital, Jinan, China.
¹⁰ Weill Institute for Neurosciences, Brain and Spinal Injury Center (BASIC), Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
¹¹ Department of Pharmacology, University of California, Davis, Davis, CA, USA.
¹² Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA, USA. Electronic address: Mervyn.Maze@UCSF.edu.

PMID: 41062364
PMCID: PMC12799455 (available on 2026-12-01)
DOI: 10.1016/j.bja.2025.09.003

No abstract available

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Figures

**Fig 3**
Phenoxyalkoxypsoralen-1 (PAP-1) attenuates surgery-induced microglial activation. Mice with diet-induced obesity (DIO) were randomised to three groups (n=8 per group) that received neither surgery nor PAP-1 (DIO+sham), surgery alone with no PAP-1 (DIO+surgery), or surgery together with PAP-1 (DIO+surgery+PAP-1). After surgery, mice not randomised to receive PAP-1 (DIO+sham; DIO+surgery) were administered MIGLYOL, and mice randomised to PAP-1 received doses intraoperatively and 12 h after surgery. At 24 h after surgery, mice were killed, and brains were perfused, fixed, and sectioned. Coronal sections (35 mm thick) from the dentate gyrus were stained with anti-Iba1 antibody. Immunofluorescence was performed with Alexa Fluor 488-labelled anti-rabbit antibody. (a) Representative photomicrographs from each of the groups. The upper panel represents 4′,6-diamidino-2-phenylindole (DAPI) staining, the middle panel staining for Iba1, and the lower panel a higher magnification. The internal scale marker represents 50 mm. (b) Iba1+ cells were counted manually by visual inspection of hippocampal sections of anatomically matched photomicrographs, with an average taken from four sequential sections per mouse. (c) To analyse microglial cell-body size (in pixels), each section was processed in a systematic way to create a binary image by applying a previously established threshold. (d) Iba1 fluorescence intensity (absorbance unit [AU]) was similarly measured with ImageJ from images captured using identical exposure times that also avoided saturating pixel intensities. Data (mean [standard deviation]) were analysed by one-way analysis of variance followed by Bonferroni *post hoc* test. ∗P=0.0012; ∗∗∗P<0.001.

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Erratum for

Blocking Kv1.3 potassium channels prevents postoperative neuroinflammation and cognitive decline without impairing wound healing in mice.
Lai IK, Valdearcos M, Morioka K, Saxena S, Feng X, Li R, Uchida Y, Lijun A, Li W, Pan J, Koliwad S, Marcucio R, Wulff H, Maze M. Lai IK, et al. Br J Anaesth. 2020 Sep;125(3):298-307. doi: 10.1016/j.bja.2020.05.018. Epub 2020 Jul 2. Br J Anaesth. 2020. PMID: 32624183 Free PMC article.

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Corrigendum to 'Blocking Kv1.3 potassium channels prevents postoperative neuroinflammation and cognitive decline without impairing wound healing in mice' (Br J Anaesth 2020; 125: 298-307)

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Corrigendum to 'Blocking Kv1.3 potassium channels prevents postoperative neuroinflammation and cognitive decline without impairing wound healing in mice' (Br J Anaesth 2020; 125: 298-307)

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