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. 2025 Aug 25;3(4):qyaf110.
doi: 10.1093/ehjimp/qyaf110. eCollection 2025 Oct.

Point-of-care ultrasound vs. routine transthoracic echocardiography for screening of cardiovascular disease in pregnant women

Sabha Bhatti  1   2 , Shakeela Naz  1 , Sumyia Gurmani  1 , Wajid Hussain  1 , Uzma Atif  1 , Shazia Ahmed  1 , Kiran Zahra  1 , Haleema Yasmin  3 , Ali Khan  4 , Musa Karim  1 , Abdul Hakeem  1
Affiliations

Point-of-care ultrasound vs. routine transthoracic echocardiography for screening of cardiovascular disease in pregnant women

Sabha Bhatti et al. Eur Heart J Imaging Methods Pract. .

Abstract

Aims: The Prospective Pakistan Registry of Echocardiographic Screening in Asymptomatic Pregnant Women (PRESAP) is a registry designed for the echocardiographic screening of structural heart disease (SHD). It offers a unique opportunity to compare the effectiveness of point-of-care ultrasound (POCUS) vs. routine transthoracic echocardiography (TTE) in this population. This sub-study of the PRESAP registry aimed to compare the detection of SHD in asymptomatic pregnant women using POCUS vs. routine TTE.

Methods and results: Between February 2023 and March 2024, pregnant women without known heart disease were enrolled in the PRESAP registry. Participants underwent a limited echocardiogram, using either POCUS or TTE. The primary outcome was the detection of abnormal findings, including left ventricular systolic dysfunction (LVSD), valvular heart disease (VHD), and congenital heart disease (CHD). Matching cohorts were created using propensity score matching, based on demographic factors, comorbid conditions, and gestational history. Among 18 401 patients, 9681 (52.6%) underwent POCUS. The 1:1 propensity-matched cohort included 4177 patients in each arm. Abnormal echocardiographic findings were detected in 4.4% (185) of the TTE group and 3% (124) of the POCUS group (P < 0.001). VHD (1.3% vs. 1.1%; P = 0.416) and CHD (0.4% vs. 0.6%; P = 0.093) were detected at similar rates by both methods, while LVSD was more frequently identified by TTE compared with POCUS (2.8% vs. 1.5%; P < 0.001).

Conclusion: POCUS may be considered as an alternative to TTE for screening for SHD in asymptomatic pregnant women, particularly in resource-limited settings. TTE was superior for LVSD, and POCUS was equally effective in identifying valvular and congenital heart disease.

Keywords: cardiovascular disease; point-of-care ultrasound; pregnancy; transthoracic echocardiography.

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Conflict of interest statement

Conflict of interest: None declared.

Figures

Graphical Abstract
Graphical Abstract
Prevalence of abnormal echocardiographic findings in unmatched and matched cohorts of TTE and POCUS.
Figure 1
Figure 1
The distribution of propensity score in unmatched and matched cohorts of TTE and POCUS.
See this image and copyright information in PMC

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