A human pan-disease blood atlas of the circulating proteome

María Bueno Álvez¹, Sofia Bergström¹, Josefin Kenrick¹, Emil Johansson¹, Mikael Åberg², Murat Akyildiz³, Ozlem Altay¹, Hilda Sköld^{1

4}, Konstantinos Antonopoulos¹, Emmanouil Apostolakis¹, Yasin Hasan Balcioglu⁵, Anna Bergström⁶, Göran Bergström^{7

8}, Sophia Björkander⁹, Suzanne Egyhazi Brage¹⁰, Petter Brodin^{11

12}, Lynn Butler^{1

13

14}, Sara Cajander¹⁵, Hanna Danielsson^{11

16}, Murat Dayangac¹⁷, Gizem Dinler-Doganay¹⁸, Levent Doğanay^{19

20}, Gunilla Enblad²¹, Malin Enblad²², Linn Fagerberg^{1

4}, Sara Falck-Jones^{23

24}, Anna Färnert^{23

24

25}, Mattias Forsberg¹, Laura Gonzalez¹¹, Anders Gummesson^{7

26}, Karin Gunnarsson^{23

27}, Iva Gunnarsson^{23

27}, Ulf Gyllensten²⁸, Göran Hesselager²⁹, Andreas Hober¹, Martin Höglund²⁹, Marie Holmqvist^{23

27}, Begum Horuluoglu^{23

24}, Rebecka Hultgren^{13

30}, Maria Jesus Iglesias¹, Helena Janols²⁹, Fredric Johansson¹, Anette Johnsson¹¹, Lars Klareskog²³, David Kotol¹, Inger Kull^{9

16}, Marika Kvarnström²³, Maximilian Julius Lautenbach^{23

24

25}, Ulrika Liljedahl², Henrik Lindman²¹, Cecilia Lindskog²¹, Miklos Lipcsey²², Ingrid E Lundberg^{23

24

27}, Adil Mardinoglu^{1

31}, Erik Melén^{9

16}, Lingqi Meng¹, Anne-Sophie Merritt⁶, Jan Mulder³², Mai Thi-Huyen Nguyen¹, Jessica Nordlund², Anna Norrby-Teglund³³, Antonella Notarnicola^{23

27}, Piotr Nowak^{25

34}, Jacob Odeberg^{1

14

23}, Per Oksvold¹, Tomas Olsson³⁵, Leonid Padyukov²³, Karlis Pauksens²⁹, Fredrik Piehl³⁵, Elisa Pin¹, Fredrik Pontén²¹, Natallia Rameika²¹, Anton Reepalu^{36

37}, Joy Roy^{13

30}, Jochen M Schwenk^{1

16}, Meltem Sen⁵, Antti Siika¹³, Oscar E Simonson²², Åsa Sivertsson¹, Tobias Sjöblom²¹, Evelina Sjöstedt¹, Lovisa Skoglund¹, Anna Smed-Sörensen^{23

24}, Klara Sondén²³, Anders Sönnerborg^{34

38}, Karin Stålberg³⁹, Kristoffer Strålin^{25

34}, Jonas Sundén-Cullberg^{25

34}, Christopher Sundling^{23

24

25}, Thanadol Sutantiwanichkul¹, Fernanda Costa Svedman^{10

40}, Mattias Svensson³³, Elisabet Svenungsson^{23

27}, Tadepally Lakshmikanth¹¹, Khue Hua Tran-Minh¹, Hasan Türkez⁴¹, Christian Unge^{42

43}, Per Venge²⁹, Marie Wahren-Herlenius^{23

44}, Jakob Woessmann¹, Hong Yang¹, Umit Haluk Yeşilkaya⁴⁵, Meng Yuan¹, Mujdat Zeybel³, Cheng Zhang^{1

31}, Wen Zhong⁴⁶, Martin Zwahlen¹, Kalle von Feilitzen¹, Peter Nilsson¹, Fredrik Edfors¹, Mathias Uhlén^{1

32}

Affiliations

¹ Department of Protein Science, SciLifeLab, KTH Royal Institute of Technology, Stockholm, Sweden.
² Department of Medical Sciences, and SciLifeLab, Uppsala University, Uppsala, Sweden.
³ Department of Gastroenterology and Hepatology, School of Medicine, Koç University, Istanbul, Turkey.
⁴ Proteomic Sciences, Olink, part of Thermo Fisher Scientific, Uppsala, Sweden.
⁵ Bakirkoy Prof. Mazhar Osman Training and Research Hospital for Psychiatry, Neurology and Neurosurgery, Istanbul, Turkey.
⁶ Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, and Centre for Occupational and Environmental Medicine, Region Stockholm, Stockholm, Sweden.
⁷ Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
⁸ Department of Clinical Physiology, Sahlgrenska University Hospital, Region Västra Götaland, Gothenburg, Sweden.
⁹ Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.
¹⁰ Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.
¹¹ Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.
¹² Medical Research Council, Laboratory of Medical Sciences (LMS), Imperial College Hammersmith Campus, London, UK.
¹³ Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
¹⁴ Department of Clinical Medicine, The Arctic University of Norway, Tromsø, Norway.
¹⁵ Department of Infectious Diseases, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
¹⁶ Sachs Children's and Youth Hospital, Södersjukhuset, Stockholm, Sweden.
¹⁷ Department of General Surgery, Medipol University, Istanbul, Turkey.
¹⁸ Department of Molecular Biology and Genetics, Istanbul Technical University, Istanbul, Turkey.
¹⁹ Gastroenterology and Hepatology Unit, VM Pendik Medicalpark Teaching Hospital, Istanbul, Turkey.
²⁰ Department of Internal Medicine, Bahçeşehir University (BAU), Istanbul, Turkey.
²¹ Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
²² Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.
²³ Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
²⁴ Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.
²⁵ Department of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden.
²⁶ Region Västra Götaland, Department of Clinical Genetics and Genomics, Sahlgrenska University Hospital, Gothenburg, Sweden.
²⁷ Department of Gastroenterology, Dermatology and Rheumatology, Karolinska University Hospital, Stockholm, Sweden.
²⁸ Department of Immunology, Genetics, and Pathology, Biomedical Center, SciLifeLab Uppsala, Uppsala University, Uppsala, Sweden.
²⁹ Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
³⁰ Department of Vascular Surgery, Karolinska University Hospital, Stockholm, Sweden.
³¹ Centre for Host-Microbiome Interactions (CHMI), King's College London, London, UK.
³² Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden.
³³ Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Flemingsberg, Sweden.
³⁴ Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.
³⁵ Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
³⁶ Department of Translational Medicine, Lund University, Lund, Sweden.
³⁷ Department of Infectious Diseases, Skåne University Hospital, Malmö, Sweden.
³⁸ Department of Clinical Microbiology, Karolinska University Hospital, Stockholm, Sweden.
³⁹ Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
⁴⁰ Theme Cancer, Skin Cancer Center, Karolinska University Hospital, Stockholm, Sweden.
⁴¹ Department of Medical Biology, Faculty of Medicine, Ataturk University, Erzurum, Turkey.
⁴² Department of Emergency Medicine, Karolinska University Hospital, Stockholm, Sweden.
⁴³ Department of Medicine, Danderyd Hospital, Stockholm, Sweden.
⁴⁴ The University of Bergen, Bergen, Norway.
⁴⁵ Beth Israel Deaconess Medical Center, Department of Neurology, Harvard Medical School, Boston, MA, USA.
⁴⁶ Department of Biomedical and Clinical Sciences, SciLifeLab, Linköping University, Linköping, Sweden.

PMID: 41066540
DOI: 10.1126/science.adx2678

A human pan-disease blood atlas of the circulating proteome

María Bueno Álvez et al. Science. 2025.

. 2025 Oct 9:eadx2678.

doi: 10.1126/science.adx2678. Online ahead of print.

Authors

Affiliations

¹ Department of Protein Science, SciLifeLab, KTH Royal Institute of Technology, Stockholm, Sweden.
² Department of Medical Sciences, and SciLifeLab, Uppsala University, Uppsala, Sweden.
³ Department of Gastroenterology and Hepatology, School of Medicine, Koç University, Istanbul, Turkey.
⁴ Proteomic Sciences, Olink, part of Thermo Fisher Scientific, Uppsala, Sweden.
⁵ Bakirkoy Prof. Mazhar Osman Training and Research Hospital for Psychiatry, Neurology and Neurosurgery, Istanbul, Turkey.
⁶ Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, and Centre for Occupational and Environmental Medicine, Region Stockholm, Stockholm, Sweden.
⁷ Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
⁸ Department of Clinical Physiology, Sahlgrenska University Hospital, Region Västra Götaland, Gothenburg, Sweden.
⁹ Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.
¹⁰ Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.
¹¹ Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.
¹² Medical Research Council, Laboratory of Medical Sciences (LMS), Imperial College Hammersmith Campus, London, UK.
¹³ Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
¹⁴ Department of Clinical Medicine, The Arctic University of Norway, Tromsø, Norway.
¹⁵ Department of Infectious Diseases, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
¹⁶ Sachs Children's and Youth Hospital, Södersjukhuset, Stockholm, Sweden.
¹⁷ Department of General Surgery, Medipol University, Istanbul, Turkey.
¹⁸ Department of Molecular Biology and Genetics, Istanbul Technical University, Istanbul, Turkey.
¹⁹ Gastroenterology and Hepatology Unit, VM Pendik Medicalpark Teaching Hospital, Istanbul, Turkey.
²⁰ Department of Internal Medicine, Bahçeşehir University (BAU), Istanbul, Turkey.
²¹ Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
²² Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.
²³ Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
²⁴ Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.
²⁵ Department of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden.
²⁶ Region Västra Götaland, Department of Clinical Genetics and Genomics, Sahlgrenska University Hospital, Gothenburg, Sweden.
²⁷ Department of Gastroenterology, Dermatology and Rheumatology, Karolinska University Hospital, Stockholm, Sweden.
²⁸ Department of Immunology, Genetics, and Pathology, Biomedical Center, SciLifeLab Uppsala, Uppsala University, Uppsala, Sweden.
²⁹ Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
³⁰ Department of Vascular Surgery, Karolinska University Hospital, Stockholm, Sweden.
³¹ Centre for Host-Microbiome Interactions (CHMI), King's College London, London, UK.
³² Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden.
³³ Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Flemingsberg, Sweden.
³⁴ Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.
³⁵ Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
³⁶ Department of Translational Medicine, Lund University, Lund, Sweden.
³⁷ Department of Infectious Diseases, Skåne University Hospital, Malmö, Sweden.
³⁸ Department of Clinical Microbiology, Karolinska University Hospital, Stockholm, Sweden.
³⁹ Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
⁴⁰ Theme Cancer, Skin Cancer Center, Karolinska University Hospital, Stockholm, Sweden.
⁴¹ Department of Medical Biology, Faculty of Medicine, Ataturk University, Erzurum, Turkey.
⁴² Department of Emergency Medicine, Karolinska University Hospital, Stockholm, Sweden.
⁴³ Department of Medicine, Danderyd Hospital, Stockholm, Sweden.
⁴⁴ The University of Bergen, Bergen, Norway.
⁴⁵ Beth Israel Deaconess Medical Center, Department of Neurology, Harvard Medical School, Boston, MA, USA.
⁴⁶ Department of Biomedical and Clinical Sciences, SciLifeLab, Linköping University, Linköping, Sweden.

PMID: 41066540
DOI: 10.1126/science.adx2678

Abstract

The human blood proteome provides a holistic readout of health states through the assessment of thousands of circulating proteins. Here, we present a pan-disease resource to enable the study of diverse disease phenotypes within a harmonized proteomics dataset. By profiling protein concentrations across 59 diseases and healthy cohorts, we identified proteins associated with age, sex, and BMI, as well as disease-specific signatures. This study highlights shared and distinct protein patterns across conditions, demonstrating the power of a unified proteomics approach to uncover biological insights. The dataset, covering 8,262 individuals and up to 5,416 proteins, serves as an online resource for exploring disease-specific protein profiles and advancing precision medicine research.

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A human pan-disease blood atlas of the circulating proteome

Affiliations

A human pan-disease blood atlas of the circulating proteome

Authors

Affiliations

Abstract

LinkOut - more resources

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