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. 2025 Oct 8;33(10):1645-1647.
doi: 10.1016/j.chom.2025.09.002.

Metabolic tug-of-war: Mitochondria starve Toxoplasma of folate

Evie R Hodgson  1 , Diana Stojanovski  2
Affiliations

Metabolic tug-of-war: Mitochondria starve Toxoplasma of folate

Evie R Hodgson et al. Cell Host Microbe. .

Abstract

In a recent Science paper, Medeiros et al. describe how infected cells use mitochondria as metabolic guardians, outcompeting Toxoplasma parasites for folate, an essential vitamin for DNA synthesis. This metabolic immunity strategy transforms the cell's powerhouse to an active defender, sequestering nutrients away from invaders in a metabolic tug-of-war.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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