Competing interests: The BMJ has judged that there are no disqualifying financial ties to commercial companies. TAY is an NIHR Clinical Lecturer, funded by the National Institute for Health and Care Research. The views expressed in this publication are those of the authors and not necessarily those of the NHS, the NIHR, or the Department of Health and Social Care. TAY has worked on studies that received material support from Pasante, GSK, and Sanofi, and was Associate PI on the RECOVERY trial. He sits on the TB Prevention Taskforce at TB Think Tank. He is on the steering committee of the International Tuberculosis Host Genetics Consortium. JLP is Chair of UK Academics & Professionals to End TB. RV has worked on studies and is listed as inventor on a South African patent for the CREDO device (PA3879ZA00).