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. 2025 Oct 10:S1471-4914(25)00237-0.
doi: 10.1016/j.molmed.2025.09.010. Online ahead of print.

Therapeutic roles of hyaluronan and synthases in cartilage

Gengyun Le-Chan  1 , Sunny S K Chan  2 , Cindy A Thomas-Charles  1 , Yingcui Li  3 , Kevin W-H Lo  4
Affiliations

Therapeutic roles of hyaluronan and synthases in cartilage

Gengyun Le-Chan et al. Trends Mol Med. .

Abstract

Hyaluronan synthases (HASs) are essential enzymes for hyaluronic acid (HA) production; a key component for joint lubrication and cartilage health. Dysregulated HA synthesis contributes to joint dysfunction. In this Forum, we discuss the role of HAS in matrix assembly, inflammation and the pathogenesis of osteoarthritis (OA).

Keywords: cartilage; hyaluronic acid synthases; joint; musculoskeletal; osteoarthritis.

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Conflict of interest statement

Declaration of interests The authors declare no conflicts of interest. There are no financial or non-financial relationships that could be perceived to influence the content of this manuscript. All authors affirm that they have no competing interests to disclose.

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