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Editorial
. 2025 Oct 24;121(12):1798-1800.
doi: 10.1093/cvr/cvaf163.

Tirzepatide protects the heart from doxorubicin-induced cardiotoxicity by modulating endoplasmic reticulum (ER) stress and HMGCoA reductase 1 expression

Affiliations
Editorial

Tirzepatide protects the heart from doxorubicin-induced cardiotoxicity by modulating endoplasmic reticulum (ER) stress and HMGCoA reductase 1 expression

Christopher C Glembotski. Cardiovasc Res. .
No abstract available

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Conflict of interest statement

Conflict of interest: none declared.

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References

    1. Zheng Z, Zong Y, Ma Y, Tian Y, Pang Y, Zhang C, Gao J. Glucagon-like peptide-1 receptor: mechanisms and advances in therapy. Signal Transduct Target Ther 2024;9:234. - PMC - PubMed
    1. Keene HJ, Keene AJ. Dental caries prevalence in early Hawaiian children. Pediatr Dent 1985;7:271–277. - PubMed
    1. Wu Q, Li D, Huang C, Zhang G, Wang Z, Liu J, Yu H, Song B, Zhang N, Li B, Chu X. Glucose control independent mechanisms involved in the cardiovascular benefits of glucagon-like peptide-1 receptor agonists. Biomed Pharmacother 2022;153:113517. - PubMed
    1. Linders AN, Dias IB, Lopez Fernandez T, Tocchetti CG, Bomer N, Van der Meer P. A review of the pathophysiological mechanisms of doxorubicin-induced cardiotoxicity and aging. NPJ Aging 2024;10:9. - PMC - PubMed
    1. Yang D, Chen YH, Chen YK, Zeng YL, Ling ZY. Tirzepatide alleviates doxorubicin-induced cardiotoxicity via inhibiting HRD1-mediated Nrf2 ubiquitination. Cardiovasc Res 2025;121:1865–1882. - PubMed

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