Tirzepatide protects the heart from doxorubicin-induced cardiotoxicity by modulating endoplasmic reticulum (ER) stress and HMGCoA reductase 1 expression
- PMID: 41077767
- PMCID: PMC12551385
- DOI: 10.1093/cvr/cvaf163
Tirzepatide protects the heart from doxorubicin-induced cardiotoxicity by modulating endoplasmic reticulum (ER) stress and HMGCoA reductase 1 expression
Conflict of interest statement
Conflict of interest: none declared.
Comment on
-
Tirzepatide alleviates doxorubicin-induced cardiotoxicity via inhibiting HRD1-mediated Nrf2 ubiquitination.Cardiovasc Res. 2025 Oct 24;121(12):1865-1882. doi: 10.1093/cvr/cvaf033. Cardiovasc Res. 2025. PMID: 40036855
References
-
- Keene HJ, Keene AJ. Dental caries prevalence in early Hawaiian children. Pediatr Dent 1985;7:271–277. - PubMed
-
- Wu Q, Li D, Huang C, Zhang G, Wang Z, Liu J, Yu H, Song B, Zhang N, Li B, Chu X. Glucose control independent mechanisms involved in the cardiovascular benefits of glucagon-like peptide-1 receptor agonists. Biomed Pharmacother 2022;153:113517. - PubMed
-
- Yang D, Chen YH, Chen YK, Zeng YL, Ling ZY. Tirzepatide alleviates doxorubicin-induced cardiotoxicity via inhibiting HRD1-mediated Nrf2 ubiquitination. Cardiovasc Res 2025;121:1865–1882. - PubMed
Publication types
Grants and funding
LinkOut - more resources
Full Text Sources
