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Case Reports
. 2025 Sep 10;17(9):e92024.
doi: 10.7759/cureus.92024. eCollection 2025 Sep.

Tongkat Ali-Induced Atrial Flutter: A Probable Case

Affiliations
Case Reports

Tongkat Ali-Induced Atrial Flutter: A Probable Case

Mohamed Ali. Cureus. .

Abstract

We present the case of a 71-year-old gentleman who developed new-onset atrial flutter following the initiation of Tongkat Ali (Eurycoma longifolia) supplementation. He presented with a four-day history of palpitations and dizziness. Initial workup revealed normal laboratory values, including thyroid function and electrolytes. An electrocardiogram showed supraventricular tachycardia with a heart rate of 130 bpm, which, after adenosine administration, a clear atrial flutter. Secondary causes for atrial flutter were ruled out. Given the temporal association and the absence of other predisposing factors, his atrial flutter is presumed to be Tongkat Ali-induced, representing the first documented case in the literature. This case highlights the importance of considering herbal supplements as potential triggers for cardiac arrhythmias and underscores the need for increased awareness and further research into their cardiovascular safety profiles.

Keywords: atrial flutter rapid ventricular response; herbal supplements; supra ventricular tachycardia; testosterone supplements; tongkat ali.

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Conflict of interest statement

Human subjects: Informed consent for treatment and open access publication was obtained or waived by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.

Figures

Figure 1
Figure 1. Tongkat Ali supplement label showing 668 mg extract per capsule with 2% eurycomanone content taken by the patient.
Figure 2
Figure 2. ECG showing supraventricular tachycardia (145 bpm, narrow QRS).
Figure 3
Figure 3. ECG Strip Before and After Adenosine Administration Revealing Atrial Flutter.
Figure 4
Figure 4. M-mode echocardiogram showing normal aortic root diameter (2.2 cm) and normal left atrial diameter (3.1 cm).
Figure 5
Figure 5. M-mode echocardiogram demonstrating normal left ventricular dimensions and normal function with ejection fraction of 72%.

References

    1. Complementary and alternative medicine use among adults and children: United States, 2007. Barnes PM, Bloom B, Nahin RL. https://stacks.cdc.gov/view/cdc/5266 Natl Health Stat Report. 2008;12:1–23. - PubMed
    1. Tongkat Ali (Eurycoma longifolia Jack): a review on its ethnobotany and pharmacological importance. Bhat R, Karim AA. Fitoterapia. 2010;81:669–679. - PubMed
    1. Use of herbal products and potential interactions in patients with cardiovascular diseases. Tachjian A, Maria V, Jahangir A. J Am Coll Cardiol. 2010;55:515–525. - PMC - PubMed
    1. A classification of atrial flutter and regular atrial tachycardia according to electrophysiological mechanisms and anatomical bases; a Statement from a Joint Expert Group from The Working Group of Arrhythmias of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Saoudi N, Cosío F, Waldo A, et al. Eur Heart J. 2001;22:1162–1182. - PubMed
    1. Herb-drug interactions. Fugh-Berman A. Lancet. 2000;355:134–138. - PubMed

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