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. 2025 Oct 8:1753495X251378590.
doi: 10.1177/1753495X251378590. Online ahead of print.

Stiff person syndrome and type 1 diabetes in pregnancy

Kavita Narula  1 , Victoria Singh Curry  1 , Kerry Munro  1 , Mandish K Dhanjal  1 , Charlotte Frise  1
Affiliations

Stiff person syndrome and type 1 diabetes in pregnancy

Kavita Narula et al. Obstet Med. .

Abstract

Stiff Person Syndrome (SPS) is a rare autoimmune neurological disorder linked to anti-GAD antibodies, marked by muscle rigidity, spasms, and heightened sensitivity to stimuli, predominantly affecting axial muscles. Managing SPS during pregnancy is complex and necessitates a multidisciplinary approach. This case report details the management of a 32-year-old pregnant woman with SPS and type 1 diabetes mellitus. Diagnosed 10 years prior to pregnancy, her SPS was managed with intravenous immunoglobulin, diazepam, and baclofen. During pregnancy, adjustments were made to minimise potential risks; diazepam was replaced with clonazepam near delivery to support breastfeeding, and IVIG dosing was modified based on symptoms. Her type 1 diabetes remained well controlled with an insulin pump. Delivery planning addressed risks of SPS spasms, shoulder dystocia, and caesarean recovery. This case highlights the importance of individualised care and collaboration among specialists in managing pregnancy with SPS.

Keywords: Stiff Person Syndrome; anti-GAD; type 1 diabetes.

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Conflict of interest statement

The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

References

    1. Vlad B, Wang Y, Newsome SDet al. et al. Stiff person spectrum disorders—an update and outlook on clinical, pathophysiological and treatment perspectives. Biomedicines 2023; 11: 2500. - PMC - PubMed
    1. Crane PD, Sillau S, Dreher R, et al. Population-Based study of the epidemiology of Stiff Person Syndrome in a large Colorado-based health system. Neurology [Internet] 2024; 103: e210078. - PMC - PubMed
    1. Rathbun JT, Imber J. Stiff Person Syndrome and Type 1 Diabetes mellitus: a case of the chicken or the egg? J Gen Intern Med 2019; 34: 1053–1057. - PMC - PubMed
    1. Bose S, Jacob S. Stiff-person syndrome. Pract Neurol [Internet] 2024; 25: 6–17. - PubMed
    1. Nolan JD, Nicholas JA. Stiff-Person Syndrome: Treatment consists of immunomodulatory therapies and symptom management. 2020 Sept;61–4.

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