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Review
. 2025 Oct 8:1753495X251380057.
doi: 10.1177/1753495X251380057. Online ahead of print.

Gitelman's and Bartter's syndromes in pregnancy - a systematic review

Andrew It Hebbard  1 , Kathy Paizis  1   2   3   4 , Briony A Cutts  1   2
Affiliations
Review

Gitelman's and Bartter's syndromes in pregnancy - a systematic review

Andrew It Hebbard et al. Obstet Med. .

Abstract

Background: : Gitelman's syndrome (GS) and Bartter's syndrome (BS) are rare renal disorders causing electrolyte disturbances, with physiological changes of pregnancy potentially worsening symptoms and electrolyte derangement.

Methods: A literature search of electronic databases was conducted using terms describing (1) GS or BS and (2) pregnancy, and the quality of studies was graded using the NIH/NHLBI quality assessment tool. Data collected included measures of maternal and neonatal outcomes, pregnancy information, and details of treatment, diagnosis, and electrolyte monitoring.

Results: Fifty-eight pregnancies in 52 women were reported in GS, and 55 pregnancies in 27 women were reported in BS. Adverse events and symptoms, including intrauterine growth restriction, oligohydramnios, preterm birth, fatigue, weakness, and paraesthesia, were commonly reported. The mainstay of therapy remains oral and intravenous electrolyte replacement coupled with frequent monitoring.

Conclusions: The management of GS and BS in pregnancy presents a challenge and has the potential for significant maternal and neonatal morbidity.

Keywords: Bartter's syndrome; Gitelman's syndrome; pregnancy; systematic review.

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Conflict of interest statement

The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
PRISMA flow diagram.
See this image and copyright information in PMC

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