Yapping Less, Contracting More: TAX1BP3 as a Regulator of Vascular Smooth Muscle Differentiation and Therapeutic Target

Sizhao Lu^{1

2}, Mary C M Weiser-Evans^{1

2

3

4}

Affiliations

¹ Department of Medicine, Division of Renal Diseases and Hypertension (S.L., M.C.M.W.-E.), University of Colorado Anschutz Medical Campus, Aurora.
² School of Medicine, Consortium for Fibrosis Research and Translation (S.L., M.C.M.W.-E.), University of Colorado Anschutz Medical Campus, Aurora.
³ Medical Scientist Training Program, University of Colorado School of Medicine (M.C.M.W.-E.), University of Colorado Anschutz Medical Campus, Aurora.
⁴ Cardiovascular Pulmonary Research Program (M.C.M.W.-E.), University of Colorado Anschutz Medical Campus, Aurora.

Editorial

Sizhao Lu et al. Circulation. 2025.

. 2025 Oct 14;152(15):1109-1112.

doi: 10.1161/CIRCULATIONAHA.125.076355. Epub 2025 Oct 13.

Sizhao Lu^{1

2}, Mary C M Weiser-Evans^{1

2

3

4}

¹ Department of Medicine, Division of Renal Diseases and Hypertension (S.L., M.C.M.W.-E.), University of Colorado Anschutz Medical Campus, Aurora.
² School of Medicine, Consortium for Fibrosis Research and Translation (S.L., M.C.M.W.-E.), University of Colorado Anschutz Medical Campus, Aurora.
³ Medical Scientist Training Program, University of Colorado School of Medicine (M.C.M.W.-E.), University of Colorado Anschutz Medical Campus, Aurora.
⁴ Cardiovascular Pulmonary Research Program (M.C.M.W.-E.), University of Colorado Anschutz Medical Campus, Aurora.

No abstract available

Keywords: Editorials; atherosclerosis; muscle, smooth, vascular; vascular remodeling.

Conflict of interest statement

None.

TAX1BP3 Is a SUMOylated Nucleocytoplasmic Shuttling Protein and Protects Against Vascular Neointimal Hyperplasia.
Yang H, Zhong Y, Guo W, Guo W, Chen B, Lin Z, Zhang Q, Zou R, Cao X, Li F, Feng W, Yan J, Zeng Z, Wang W, Ouyang K, Xu X, Fan X, Fang X, Ai S, Liu C. Yang H, et al. Circulation. 2025 Oct 14;152(15):1087-1108. doi: 10.1161/CIRCULATIONAHA.124.072525. Epub 2025 Sep 16. Circulation. 2025. PMID: 40955569

1. Libby P, Buring JE, Badimon L, Hansson GK, Deanfield J, Bittencourt MS, Tokgözoğlu L, Lewis EF. Atherosclerosis. Nat Rev Dis Primers. 2019;5(1):1–18. doi: 10.1038/s41572-019-0106-z - DOI - PubMed
1. Shlofmitz E, Iantorno M, Waksman R. Restenosis of Drug-Eluting Stents. Circulation: Cardiovascular Interventions. 2019;12(8):e007023. doi: 10.1161/CIRCINTERVENTIONS.118.007023 - DOI - PubMed
1. Miano JM, Fisher EA, Majesky MW. Fate and State of Vascular Smooth Muscle Cells in Atherosclerosis. Circulation. 2021;143(21):2110–2116. doi: 10.1161/CIRCULATIONAHA.120.049922 - DOI - PMC - PubMed
1. Azar P, Jarr KU, Gomez D, Jørgensen HF, Leeper NJ, Bochaton-Piallat ML. Smooth muscle cells in atherosclerosis: essential but overlooked translational perspectives. European Heart Journal. Published online June 27, 2025:ehaf337. doi: 10.1093/eurheartj/ehaf337 - DOI - PubMed
1. Fu M, Hu Y, Lan T, Guan KL, Luo T, Luo M. The Hippo signalling pathway and its implications in human health and diseases. Sig Transduct Target Ther. 2022;7(1):376. doi: 10.1038/s41392-022-01191-9 - DOI - PMC - PubMed