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. 2025 Dec:112:38-45.
doi: 10.1016/j.annepidem.2025.10.014. Epub 2025 Oct 11.

Cardiovascular disease mortality trends in young adults aged 18-34 years, United States, 2000-2023

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Cardiovascular disease mortality trends in young adults aged 18-34 years, United States, 2000-2023

Adam S Vaughan et al. Ann Epidemiol. 2025 Dec.

Abstract

Purpose: This study examines national trends in mortality from cardiovascular disease (CVD) and select subtypes among U.S. young adults aged 18-34 years from 2000 to 2023.

Methods: National mortality data from the National Vital Statistics System were used to identify CVD, heart disease, stroke, and hypertension-related CVD deaths among U.S. residents aged 18-34 from 2000 to 2023. Crude and age-standardized death rates were calculated overall and by age group, sex, and race and ethnicity. Temporal trends were calculated as percent change using a log-linear model.

Results: From 2000-2023, age-standardized CVD and heart disease death rates among young adults did not statistically change (percent change: -2.2 % [95 % CI: -7.8, 3.7] and -2.4 % [95 % CI: -8.3 %, 3.8 %], respectively). Stroke death rates decreased (percent change: -15.7 % [-21.0 %, -10.0 %])). However, hypertension-related CVD death rates increased by 78.5 % [95 % CI: 63.6 %, 94.7 %]). Patterns across demographic groups were broadly similar.

Conclusion: Despite stability or modest declines in CVD death rates among young adults, hypertension-related CVD death rates increased sharply during 2000-2023. These findings merit public health action and underscore the need for better identification and management of hypertension and other CVD risk factors among young adults.

Keywords: Cardiovascular disease; Mortality; Public health surveillance; Trends; Young adults.

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Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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