Immunohistochemical and histopathological characteristics of adenomas and adenocarcinomas of Meibomian glands in dogs

Abstract

Introduction: This study aimed to provide a comprehensive histopathological and immunohistochemical analysis of Meibomian adenomas and adenocarcinomas.

Material and methods: A total of 80 tumours were included in the study: 33 adenomas and 47 Meibomian adenocarcinomas. Ki-67, cytokeratin-7 and von Willebrand factor antibodies were used for the immunohistochemical staining.

Results: Detailed characteristics of inflammatory infiltration depending on tumor type and damage to surrounding tissue by tumour cells are presented. A close correlation was found between the structure and intensity of blood vessel proliferation and the level of factor VIII expression.

Conclusions: The presented detailed histopathological analysis, combined with the results of immunohistochemical studies, now allows for better treatment planning and prognosis assessment for patients.

Keywords: CK-7; Ki-67; Meibomian gland; adenocarcinoma; adenoma; dog; vWF.