Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1971 Dec;68(12):3130-5.
doi: 10.1073/pnas.68.12.3130.

Autoimmune-like antibodies to the ligand-binding sites of myeloma proteins

S Sirisinha, H N Eisen

Autoimmune-like antibodies to the ligand-binding sites of myeloma proteins

S Sirisinha et al. Proc Natl Acad Sci U S A. 1971 Dec.

Abstract

BALB/c mice were immunized with three A-myeloma proteins of BALB/c-2 or BALB/c origin (produced by plasmacytomas MOPC-315, MOPC-460, Adj. PC-22A). Noncross reacting antibodies were formed against Proteins-315 and 460, but the response to Protein-22A was marginal. Proteins-315 and 460 have anti-dinitrophenyl activity, and their reactions with the corresponding BALB/c antibodies were inhibited by dinitrophenyl ligands. It appears that antibodies can be formed in BALB/c mice against unique "idiotypic" determinants in the ligand-binding sites of some BALB/c mycloma proteins.

PubMed Disclaimer

References

    1. Proc R Soc Lond B Biol Sci. 1966 Nov 22;166(1003):207-21 - PubMed
    1. C R Hebd Seances Acad Sci. 1963 Jul 17;257:805-8 - PubMed
    1. Adv Immunol. 1967;7:91-145 - PubMed
    1. Biochemistry. 1968 Nov;7(11):4126-34 - PubMed
    1. Biochemistry. 1969 Jul;8(7):2729-36 - PubMed

LinkOut - more resources