Beyond anticholinergic effects: A case of trihexyphenidyl-induced bradycardia
- PMID: 41089938
- PMCID: PMC12517587
- DOI: 10.4103/jfmpc.jfmpc_113_25
Beyond anticholinergic effects: A case of trihexyphenidyl-induced bradycardia
Abstract
Anticholinergic drugs are extensively employed in clinical settings, with their side effects well-documented. However, paradoxical bradycardia due to trihexyphenidyl hydrochloride, an anticholinergic agent, is an infrequent and underreported phenomenon. This may be attributed to a lack of vigilant monitoring in patients undergoing therapy. Here, we present the case of a 12-year-old girl who developed sinus bradycardia following the administration of trihexyphenidyl. The heart rate normalized upon drug discontinuation. This report emphasizes the need for thorough cardiac monitoring, including baseline heart rate, Electrocardiogram (ECG), and electrolyte evaluation, before initiating therapy to prevent adverse outcomes.
Keywords: Adverse drug reaction; paradoxical bradycardia; trihexyphenidyl hydrochloride.
Copyright: © 2025 Journal of Family Medicine and Primary Care.
Conflict of interest statement
There are no conflicts of interest.
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