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Comment
. 2025 Oct 15;29(1):435.
doi: 10.1186/s13054-025-05681-4.

Is volatile sedation truly associated with increased mortality in mechanically ventilated critically ill adults compared to intravenous sedation? Moving beyond pairwise meta-analysis to individual agent assessment via bayesian network meta-analysis

Po-An Su  1 , Pei-Chun Lai  2   3 , Yen-Ta Huang  4
Affiliations
Comment

Is volatile sedation truly associated with increased mortality in mechanically ventilated critically ill adults compared to intravenous sedation? Moving beyond pairwise meta-analysis to individual agent assessment via bayesian network meta-analysis

Po-An Su et al. Crit Care. .
No abstract available

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Conflict of interest statement

Declarations. Ethics approval and consent to participate: Not applicable. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Bayesian network meta-analysis of mortality associated with isoflurane, sevoflurane, propofol, and midazolam in mechanically ventilated adults, presented as half-eye plots. (A) Posterior odds ratios relative to midazolam. Shaded areas represent full posterior distributions; the vertical line marks an odds ratio (OR) of 1. Blue shading indicates OR > 1 (increased mortality versus midazolam); pink shading indicates OR < 1 (decreased mortality versus midazolam). Black dots mark posterior median ORs with black lines indicating 95% credible intervals. The probability of each agent having lower mortality than midazolam (OR < 1) was: propofol 30.5%, isoflurane 31.2%, and sevoflurane 13.0%. (B) Absolute mortality probabilities based on pooled baseline risk from midazolam trials. Ridgeline density plots illustrate posterior distributions, color-coded by mortality risk categories: <5% (green), 5–15% (orange), and > 15% (red). Percentages indicate the proportion of samples in each category. Blue dots mark posterior median probabilities with blue lines indicating 95% credible intervals. Gray dashed/dotted lines and gray text represent the sensitivity analysis excluding Jabaudon 2025
See this image and copyright information in PMC

Comment on

References

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