The cyclic AMP paradox in pulmonary fibrosis: context is everything…

Brintha Selvarajah^{1

2

3}, Chris J Scotton^{4

5

6}

Affiliations

¹ UCL Respiratory, University College London, London, UK brintha.hayes@ucl.ac.uk.
² The Francis Crick Institute, London, UK.
³ University College Hospital, Respiratory Medicine, London, UK.
⁴ Department of Clinical and Biomedical Sciences, University of Exeter, Exeter, UK.
⁵ Academic Department of Respiratory Medicine, Royal Devon University Healthcare NHS Foundation Trust, Exeter, UK.
⁶ NIHR Exeter Biomedical Research Centre, University of Exeter, Exeter, UK.

Editorial

Brintha Selvarajah et al. Eur Respir J. 2025.

. 2025 Oct 16;66(4):2501382.

doi: 10.1183/13993003.01382-2025. Print 2025 Oct.

Brintha Selvarajah^{1

2

3}, Chris J Scotton^{4

5

6}

¹ UCL Respiratory, University College London, London, UK brintha.hayes@ucl.ac.uk.
² The Francis Crick Institute, London, UK.
³ University College Hospital, Respiratory Medicine, London, UK.
⁴ Department of Clinical and Biomedical Sciences, University of Exeter, Exeter, UK.
⁵ Academic Department of Respiratory Medicine, Royal Devon University Healthcare NHS Foundation Trust, Exeter, UK.
⁶ NIHR Exeter Biomedical Research Centre, University of Exeter, Exeter, UK.

No abstract available

Conflict of interest statement

Conflict of interest: The authors have no potential conflicts of interest to declare.

Pharmacological inhibition of Epac1 protects against pulmonary fibrosis by blocking FoxO3a neddylation.
Jankowski K, Lemay SE, Lozano-Ojalvo D, Pérez-Rodríguez L, Sauvaget M, Breuils-Bonnet S, Formoso K, Jagana V, Ochoa MT, Zhang S, Milara J, Cortijo J, Turnbull IC, Provencher S, Bonnet S, Ochando J, Lezoualc'h F, Bisserier M, Hadri L. Jankowski K, et al. Eur Respir J. 2025 Oct 16;66(4):2402250. doi: 10.1183/13993003.02250-2024. Print 2025 Oct. Eur Respir J. 2025. PMID: 40639873 Free PMC article.