Advancing methods for multi-ancestry genomics

Abstract

Genomics research has historically been biased toward individuals of European ancestry, which has the potential to exacerbate health inequities (Martin, A.R. et al. Clinical use of current polygenic risk scores may exacerbate health disparities). To reduce these disparities, current efforts in human genetics emphasize the inclusion of diverse populations (All of Us Research Program Investigators, The 'All of Us' Research Program). Here, we highlight recent preprints that focus on the intricacies of researching participants with multiple genetic ancestries.