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. 1972 Mar;112(5):676-80.
doi: 10.1016/0002-9378(72)90794-6.

Cross-reaction of contraceptive steroids in competitive binding assays of progesterone and estradiol

K Kharma, S Stone, I H Thorneycroft, R M Nakamura, D R Mishell Jr

Cross-reaction of contraceptive steroids in competitive binding assays of progesterone and estradiol

K Kharma et al. Am J Obstet Gynecol. 1972 Mar.

Abstract

PIP: Cross-reaction of oral contraceptives (OCs) in competitive binding assays of progesterone and estradiol was investigated. The compounds tested were chlormadinone acetate, diethylstilbestrol, dimethisterone, dydrogesterone, ethinyl estradiol, ethynodiol diacetate, megestrol acetate, mestranol, norethynodrel, norethindrone, d-norgestrel, medroxyprogesterone acetate, quinestrol, and quingestanol acetate. Only ethinyl estradiol had a cross-reaction of more than 1% (2%) in the estradiol radioimmunoassay and dydrogesterone (1.4%) and d-norgestrel (4%) were the only compounds that showed a cross-reaction more than 1% in the progesterone competitive protein-binding assay. These results indicate that the steroids tested, in doses currently being used in OCs, will not markedly interfere with the assay of endogenous estradiol and progesterone.

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