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Editorial
. 2025 Oct 1;14(5):839-842.
doi: 10.21037/hbsn-2025-393. Epub 2025 Sep 26.

Durvalumab plus cisplatin and gemcitabine in advanced biliary tract cancer: can we do it better?

Affiliations
Editorial

Durvalumab plus cisplatin and gemcitabine in advanced biliary tract cancer: can we do it better?

Margherita Rimini et al. Hepatobiliary Surg Nutr. .
No abstract available

Keywords: Cholangiocarcinoma; durvalumab; immunotherapy.

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Conflict of interest statement

Conflicts of Interest: Both authors have completed the ICMJE uniform disclosure form (available at https://hbsn.amegroups.com/article/view/10.21037/hbsn-2025-393/coif). The authors have no conflicts of interest to declare.

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References

    1. Valle J, Wasan H, Palmer DH, et al. Cisplatin plus gemcitabine versus gemcitabine for biliary tract cancer. N Engl J Med 2010;362:1273-81. 10.1056/NEJMoa0908721 - DOI - PubMed
    1. Oh DY, Ruth He A, Qin S, et al. Durvalumab plus Gemcitabine and Cisplatin in Advanced Biliary Tract Cancer. NEJM Evid 2022;1:EVIDoa2200015. - PubMed
    1. Oh DY, He AR, Bouattour M, et al. Durvalumab plus gemcitabine and cisplatin for advanced biliary tract cancer: updated overall survival from TOPAZ-1. Lancet Gastroenterol Hepatol 2024;9:694-704. 10.1016/S2468-1253(24)00095-5 - DOI - PubMed
    1. Larkin J, Chiarion-Sileni V, Gonzalez R, et al. Five-Year Survival with Combined Nivolumab and Ipilimumab in Advanced Melanoma. N Engl J Med 2019;381:1535-46. 10.1056/NEJMoa1910836 - DOI - PubMed
    1. Topalian SL, Taube JM, Pardoll DM. Neoadjuvant checkpoint blockade for cancer immunotherapy. Science 2020;367:eaax0182. 10.1126/science.aax0182 - DOI - PMC - PubMed