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. 2025 Oct 17;193(Supplement_2):ii47-ii71.
doi: 10.1093/ejendo/lvaf065.

EndoCompass project: research roadmap for diabetes, obesity, and metabolism

Chantal Mathieu  1 , Manuela Meireles  2 , Uberto Pagotto  3 , Martin Wabitsch  4 , Indraneel Banerjee  5 , Alberto Bartolomé  6   7 , Tadej Battelino  8   9 , Julia Beck  10 , Francesco Chiarelli  11 , Diva D De Leon  12   13 , Klemen Dovč  8   9 , Marwan El Ghoch  14 , Alfonso Galderisi  15 , Evelien Gevers  16 , Pieter Gillard  17 , Belma Haliloglu  18 , Henrike Hoermann  19 , Boris Mankovsky  20 , Jonathan Mertens  21   22 , Klaus Mohnike  23 , Richard Oram  24 , Tai Pasquini  25 , Ewan Pearson  26 , Thomas R Pieber  27 , Snezana Polovina  28 , Julie Raskin  25 , Marcia Roeper  19   29 , Lisa Ruck  29 , Maria Salomon Estebanez  30 , Tsvetalina Tankova  31 , Paul Thornton  32 , Elisabeth F C van Rossum  33 , Rade Vukovic  34   35 , Chris Worth  30 , Agnieszka Zachurzok  36
Affiliations

EndoCompass project: research roadmap for diabetes, obesity, and metabolism

Chantal Mathieu et al. Eur J Endocrinol. .

Abstract

Background: Endocrine science remains underrepresented in European Union research programmes despite the fundamental role of hormone health in human well-being. Analysis of the CORDIS database reveals a persistent gap between the societal impact of endocrine disorders and their research prioritization. At national funding level, endocrine societies report limited or little attention of national research funding towards endocrinology. The EndoCompass project-a joint initiative between the European Society of Endocrinology and the European Society of Paediatric Endocrinology, aimed to identify and promote strategic research priorities in endocrine science to address critical hormone-related health challenges.

Methods: Research priorities were established through comprehensive analysis of the EU CORDIS database covering the Horizon 2020 framework period (2014-2020). Expert consultation was conducted to identify key research priorities, followed by broader stakeholder engagement including society members and patient advocacy groups.

Results: Research priorities include: genetic/epigenetic factors, brain-periphery communication, and environmental influences. Key therapeutic areas include innovative approaches for monogenic disorders, incretin mimetics, dual receptor agonists, microbiome analysis, and improved behavioural interventions. For type 1 diabetes, priorities focus on early detection, insulin delivery systems, and disease-modifying therapies.

Conclusions: This component of the EndoCompass project provides an evidence-based roadmap for strategic research investment. This framework identifies crucial investigation areas into diabetes and obesity pathophysiology, prevention, and treatment strategies, ultimately aimed at reducing the burden of metabolic disorders on individuals and society. The findings support the broader EndoCompass objective of aligning research funding with areas of highest potential impact in endocrine health.

Keywords: EndoCompass; diabetes; funding; obesity; roadmap.

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Conflict of interest statement

Conflict of interest: none declared.

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