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. 2026 Jan 1;45(1):e12-e14.
doi: 10.1097/INF.0000000000004968. Epub 2025 Oct 17.

Effectiveness of Nirsevimab in Preventing Respiratory Syncytial Virus-related Burden: A Test-negative Case-control Study in Infants With Bronchiolitis in Lombardy Region, Italy

Eleonora Fusco  1 , Martina Loiodice  2 , Alice Romero  2 , Sara L'Assainato  2 , Anna Banfi  2 , Giovanni Luigi Chiaffoni  2 , Cecilia Porro  2 , Valentina Fabiano  1   2 , Francesca Izzo  3 , Valentina De Giorgis  3 , Federica Forlanini  1 , Lucia Barcellini  1 , Gianvincenzo Zuccotti  1   2 , Laura Folgori  1
Affiliations

Effectiveness of Nirsevimab in Preventing Respiratory Syncytial Virus-related Burden: A Test-negative Case-control Study in Infants With Bronchiolitis in Lombardy Region, Italy

Eleonora Fusco et al. Pediatr Infect Dis J. .

Abstract

The effectiveness of nirsevimab in preventing the burden of respiratory syncytial virus (RSV)-bronchiolitis was evaluated with a test-negative case-control study in 208 infants presenting to Emergency Department. The effectiveness was 82% against RSV infection, 78% against RSV-related hospitalization, and 84% against intensive care admission. These real-world data support its inclusion in Italian immunization programs.

Keywords: bronchiolitis; hospital admission; nirsevimab; pediatric prevention; respiratory syncytial virus.

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Conflict of interest statement

The authors have no funding or conflicts of interest to disclose.

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